Impaired tumor immune response in metastatic tumors is a selective pressure for neutral evolution in CRC cases

A Darwinian evolutionary shift occurs early in the neutral evolution of advanced colorectal carcinoma (CRC), and copy number aberrations (CNA) are essential in the transition from adenoma to carcinoma. In light of this primary evolution, we investigated the evolutionary principles of the genome that...

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Detalles Bibliográficos
Autores principales: Sakimura, Shotaro, Nagayama, Satoshi, Fukunaga, Mitsuko, Hu, Qingjiang, Kitagawa, Akihiro, Kobayashi, Yuta, Hasegawa, Takanori, Noda, Miwa, Kouyama, Yuta, Shimizu, Dai, Saito, Tomoko, Niida, Atsushi, Tsuruda, Yusuke, Otsu, Hajime, Matsumoto, Yoshihiro, Uchida, Hiroki, Masuda, Takaaki, Sugimachi, Keishi, Sasaki, Shin, Yamada, Kazutaka, Takahashi, Kazuki, Innan, Hideki, Suzuki, Yutaka, Nakamura, Hiromi, Totoki, Yasushi, Mizuno, Shinichi, Ohshima, Masanobu, Shibata, Tatsuhiro, Mimori, Koshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864431/
https://www.ncbi.nlm.nih.gov/pubmed/33476333
http://dx.doi.org/10.1371/journal.pgen.1009113

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