Cargando…
Nsp1 protein of SARS-CoV-2 disrupts the mRNA export machinery to inhibit host gene expression
The ongoing unprecedented severe acute respiratory syndrome caused by the SARS-CoV-2 outbreak worldwide has highlighted the need for understanding viral-host interactions involved in mechanisms of virulence. Here, we show that the virulence factor Nsp1 protein of SARS-CoV-2 interacts with the host m...
Autores principales: | Zhang, Ke, Miorin, Lisa, Makio, Tadashi, Dehghan, Ishmael, Gao, Shengyan, Xie, Yihu, Zhong, Hualin, Esparza, Matthew, Kehrer, Thomas, Kumar, Anil, Hobman, Tom C., Ptak, Christopher, Gao, Boning, Minna, John D., Chen, Zhijian, García-Sastre, Adolfo, Ren, Yi, Wozniak, Richard W., Fontoura, Beatriz M.A. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864571/ https://www.ncbi.nlm.nih.gov/pubmed/33547084 http://dx.doi.org/10.1126/sciadv.abe7386 |
Ejemplares similares
-
Structural Basis for Influenza Virus NS1 Protein Block of mRNA Nuclear Export
por: Zhang, Ke, et al.
Publicado: (2019) -
Influenza virus mRNAs encode determinants for nuclear export via the cellular TREX-2 complex
por: Bhat, Prasanna, et al.
Publicado: (2023) -
Chemical intervention of influenza virus mRNA nuclear export
por: Esparza, Matthew, et al.
Publicado: (2020) -
Understanding COVID-19 Pathogenesis: A Drug-Repurposing Effort to Disrupt Nsp-1 Binding to Export Machinery Receptor Complex
por: Vasudevan, Sona, et al.
Publicado: (2021) -
Nuclear speckle integrity and function require TAO2 kinase
por: Gao, Shengyan, et al.
Publicado: (2022)