Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling

Calcific aortic valve disease (CAVD) is an increasingly prevalent condition, and endothelial dysfunction is implicated in its etiology. We previously identified nitric oxide (NO) as a calcification inhibitor by its activation of NOTCH1, which is genetically linked to human CAVD. Here, we show NO res...

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Detalles Bibliográficos
Autores principales: Majumdar, Uddalak, Manivannan, Sathiyanarayanan, Basu, Madhumita, Ueyama, Yukie, Blaser, Mark C., Cameron, Emily, McDermott, Michael R., Lincoln, Joy, Cole, Susan E., Wood, Stephen, Aikawa, Elena, Lilly, Brenda, Garg, Vidu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864581/
https://www.ncbi.nlm.nih.gov/pubmed/33547080
http://dx.doi.org/10.1126/sciadv.abe3706

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