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High-resolution mapping of the neutralizing and binding specificities of polyclonal sera post-HIV Env trimer vaccination
Mapping polyclonal serum responses is critical to rational vaccine design. However, most high-resolution mapping approaches involve isolating and characterizing individual antibodies, which incompletely defines the polyclonal response. Here we use two complementary approaches to directly map the spe...
Autores principales: | Dingens, Adam S, Pratap, Payal, Malone, Keara, Hilton, Sarah K, Ketas, Thomas, Cottrell, Christopher A, Overbaugh, Julie, Moore, John P, Klasse, PJ, Ward, Andrew B, Bloom, Jesse D |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864656/ https://www.ncbi.nlm.nih.gov/pubmed/33438580 http://dx.doi.org/10.7554/eLife.64281 |
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