Valproic acid combined with cisplatin-based chemoradiation in locally advanced head and neck squamous cell carcinoma patients and associated biomarkers

BACKGROUND: Cisplatin-based chemoradiation (CCRT) offers locally advanced head and neck squamous cell carcinoma (LAHNSCC) patients high local control rate, however, relapses are frequent. Our goal was to evaluate if association of valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, with CCR...

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Detalles Bibliográficos
Autores principales: Mak, Milena Perez, Pasini, Fatima Solange, Diao, Lixia, Garcia, Fabyane O Teixeira, Takahashi, Tiago Kenji, Nakazato, Denyei, Martins, Renata Eiras, Almeida, Cristiane Maria, Kulcsar, Marco Aurelio Vamondes, Lamounier, Valdelania Aparecida, Nunes, Emily Montosa, de Souza, Isabela Cristina, Garcia, Marcio Ricardo Taveira, Amadio, Alex Vieira, Siqueira, Sheila Aparecida C., Snitcovsky, Igor Moysés Longo, Sichero, Laura, Wang, Jing, de Castro, Gilberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cancer Intelligence 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864693/
https://www.ncbi.nlm.nih.gov/pubmed/33574900
http://dx.doi.org/10.3332/ecancer.2020.1155

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