Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy

The two T cell inhibitory receptors PD-1 and TIM-3 are co-expressed during exhausted T cell differentiation, and recent evidence suggests that their crosstalk regulates T cell exhaustion and immunotherapy efficacy; however, the molecular mechanism is unclear. Here we show that PD-1 contributes to th...

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Detalles Bibliográficos
Autores principales: Yang, Riyao, Sun, Linlin, Li, Ching-Fei, Wang, Yu-Han, Yao, Jun, Li, Hui, Yan, Meisi, Chang, Wei-Chao, Hsu, Jung-Mao, Cha, Jong-Ho, Hsu, Jennifer L., Chou, Cheng-Wei, Sun, Xian, Deng, Yalan, Chou, Chao-Kai, Yu, Dihua, Hung, Mien-Chie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864927/
https://www.ncbi.nlm.nih.gov/pubmed/33547304
http://dx.doi.org/10.1038/s41467-021-21099-2

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