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The role of brain perivascular space burden in early-stage Parkinson’s disease
Perivascular space (PVS) is associated with neurodegenerative diseases, while its effect on Parkinson’s disease (PD) remains unclear. We aimed to investigate the clinical and neuroimaging significance of PVS in basal ganglia (BG) and midbrain in early-stage PD. We recruited 40 early-stage PD patient...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864928/ https://www.ncbi.nlm.nih.gov/pubmed/33547311 http://dx.doi.org/10.1038/s41531-021-00155-0 |
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author | Shen, Ting Yue, Yumei Zhao, Shuai Xie, Juanjuan Chen, Yanxing Tian, Jun Lv, Wen Lo, Chun-Yi Zac Hsu, Yi-Cheng Kober, Tobias Zhang, Baorong Lai, Hsin-Yi |
author_facet | Shen, Ting Yue, Yumei Zhao, Shuai Xie, Juanjuan Chen, Yanxing Tian, Jun Lv, Wen Lo, Chun-Yi Zac Hsu, Yi-Cheng Kober, Tobias Zhang, Baorong Lai, Hsin-Yi |
author_sort | Shen, Ting |
collection | PubMed |
description | Perivascular space (PVS) is associated with neurodegenerative diseases, while its effect on Parkinson’s disease (PD) remains unclear. We aimed to investigate the clinical and neuroimaging significance of PVS in basal ganglia (BG) and midbrain in early-stage PD. We recruited 40 early-stage PD patients and 41 healthy controls (HCs). Both PVS number and volume were calculated to evaluate PVS burden on 7 T magnetic resonance imaging images. We compared PVS burden between PD and HC, and conducted partial correlation analysis between PVS burden and clinical and imaging features. PD patients had a significantly more serious PVS burden in BG and midbrain, and the PVS number in BG was significantly correlated to the PD disease severity and L-dopa equivalent dosage. The fractional anisotropy and mean diffusivity values of certain subcortical nuclei and white matter fibers within or nearby the BG and midbrain were significantly correlated with the ipsilateral PVS burden indexes. Regarding to the midbrain, the difference between bilateral PVS burden was, respectively, correlated to the difference between fiber counts of white fiber tract passing through bilateral substantia nigra in PD. Our study suggests that PVS burden indexes in BG are candidate biomarkers to evaluate PD motor symptom severity and aid in predicting medication dosage. And our findings also highlight the potential correlations between PVS burden and both grey and white matter microstructures. |
format | Online Article Text |
id | pubmed-7864928 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-78649282021-02-16 The role of brain perivascular space burden in early-stage Parkinson’s disease Shen, Ting Yue, Yumei Zhao, Shuai Xie, Juanjuan Chen, Yanxing Tian, Jun Lv, Wen Lo, Chun-Yi Zac Hsu, Yi-Cheng Kober, Tobias Zhang, Baorong Lai, Hsin-Yi NPJ Parkinsons Dis Article Perivascular space (PVS) is associated with neurodegenerative diseases, while its effect on Parkinson’s disease (PD) remains unclear. We aimed to investigate the clinical and neuroimaging significance of PVS in basal ganglia (BG) and midbrain in early-stage PD. We recruited 40 early-stage PD patients and 41 healthy controls (HCs). Both PVS number and volume were calculated to evaluate PVS burden on 7 T magnetic resonance imaging images. We compared PVS burden between PD and HC, and conducted partial correlation analysis between PVS burden and clinical and imaging features. PD patients had a significantly more serious PVS burden in BG and midbrain, and the PVS number in BG was significantly correlated to the PD disease severity and L-dopa equivalent dosage. The fractional anisotropy and mean diffusivity values of certain subcortical nuclei and white matter fibers within or nearby the BG and midbrain were significantly correlated with the ipsilateral PVS burden indexes. Regarding to the midbrain, the difference between bilateral PVS burden was, respectively, correlated to the difference between fiber counts of white fiber tract passing through bilateral substantia nigra in PD. Our study suggests that PVS burden indexes in BG are candidate biomarkers to evaluate PD motor symptom severity and aid in predicting medication dosage. And our findings also highlight the potential correlations between PVS burden and both grey and white matter microstructures. Nature Publishing Group UK 2021-02-05 /pmc/articles/PMC7864928/ /pubmed/33547311 http://dx.doi.org/10.1038/s41531-021-00155-0 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Shen, Ting Yue, Yumei Zhao, Shuai Xie, Juanjuan Chen, Yanxing Tian, Jun Lv, Wen Lo, Chun-Yi Zac Hsu, Yi-Cheng Kober, Tobias Zhang, Baorong Lai, Hsin-Yi The role of brain perivascular space burden in early-stage Parkinson’s disease |
title | The role of brain perivascular space burden in early-stage Parkinson’s disease |
title_full | The role of brain perivascular space burden in early-stage Parkinson’s disease |
title_fullStr | The role of brain perivascular space burden in early-stage Parkinson’s disease |
title_full_unstemmed | The role of brain perivascular space burden in early-stage Parkinson’s disease |
title_short | The role of brain perivascular space burden in early-stage Parkinson’s disease |
title_sort | role of brain perivascular space burden in early-stage parkinson’s disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864928/ https://www.ncbi.nlm.nih.gov/pubmed/33547311 http://dx.doi.org/10.1038/s41531-021-00155-0 |
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