Sensing soluble uric acid by Naip1-Nlrp3 platform

Uric acid (UA), a product of purine nucleotide degradation able to initiate an immune response, represents a breakpoint in the evolutionary history of humans, when uricase, the enzyme required for UA cleavage, was lost. Despite being inert in human cells, UA in its soluble form (sUA) can increase th...

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Detalles Bibliográficos
Autores principales: Braga, Tarcio Teodoro, Davanso, Mariana Rodrigues, Mendes, Davi, de Souza, Tiago Antonio, de Brito, Anderson Fernandes, Cruz, Mario Costa, Hiyane, Meire Ioshie, de Lima, Dhemerson Souza, Nunes, Vinicius, de Fátima Giarola, Juliana, Souto, Denio Emanuel Pires, Próchnicki, Tomasz, Lauterbach, Mario, Biscaia, Stellee Marcela Petris, de Freitas, Rilton Alves, Curi, Rui, Pontillo, Alessandra, Latz, Eicke, Camara, Niels Olsen Saraiva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864962/
https://www.ncbi.nlm.nih.gov/pubmed/33547278
http://dx.doi.org/10.1038/s41419-021-03445-w

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