Genome-wide association study of serum liver enzymes implicates diverse metabolic and liver pathology

Serum liver enzyme concentrations are the most frequently-used laboratory markers of liver disease, a major cause of mortality. We conduct a meta-analysis of genome-wide association studies of liver enzymes from UK BioBank and BioBank Japan. We identified 160 previously-unreported independent alanin...

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Autores principales: Chen, Vincent L., Du, Xiaomeng, Chen, Yanhua, Kuppa, Annapurna, Handelman, Samuel K., Vohnoutka, Rishel B., Peyser, Patricia A., Palmer, Nicholette D., Bielak, Lawrence F., Halligan, Brian, Speliotes, Elizabeth K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865025/
https://www.ncbi.nlm.nih.gov/pubmed/33547301
http://dx.doi.org/10.1038/s41467-020-20870-1
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author Chen, Vincent L.
Du, Xiaomeng
Chen, Yanhua
Kuppa, Annapurna
Handelman, Samuel K.
Vohnoutka, Rishel B.
Peyser, Patricia A.
Palmer, Nicholette D.
Bielak, Lawrence F.
Halligan, Brian
Speliotes, Elizabeth K.
author_facet Chen, Vincent L.
Du, Xiaomeng
Chen, Yanhua
Kuppa, Annapurna
Handelman, Samuel K.
Vohnoutka, Rishel B.
Peyser, Patricia A.
Palmer, Nicholette D.
Bielak, Lawrence F.
Halligan, Brian
Speliotes, Elizabeth K.
author_sort Chen, Vincent L.
collection PubMed
description Serum liver enzyme concentrations are the most frequently-used laboratory markers of liver disease, a major cause of mortality. We conduct a meta-analysis of genome-wide association studies of liver enzymes from UK BioBank and BioBank Japan. We identified 160 previously-unreported independent alanine aminotransferase, 190 aspartate aminotransferase, and 199 alkaline phosphatase genome-wide significant associations, with some affecting multiple different enzymes. Associated variants implicate genes that demonstrate diverse liver cell type expression and promote a range of metabolic and liver diseases. These findings provide insight into the pathophysiology of liver and other metabolic diseases that are associated with serum liver enzyme concentrations.
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spelling pubmed-78650252021-02-16 Genome-wide association study of serum liver enzymes implicates diverse metabolic and liver pathology Chen, Vincent L. Du, Xiaomeng Chen, Yanhua Kuppa, Annapurna Handelman, Samuel K. Vohnoutka, Rishel B. Peyser, Patricia A. Palmer, Nicholette D. Bielak, Lawrence F. Halligan, Brian Speliotes, Elizabeth K. Nat Commun Article Serum liver enzyme concentrations are the most frequently-used laboratory markers of liver disease, a major cause of mortality. We conduct a meta-analysis of genome-wide association studies of liver enzymes from UK BioBank and BioBank Japan. We identified 160 previously-unreported independent alanine aminotransferase, 190 aspartate aminotransferase, and 199 alkaline phosphatase genome-wide significant associations, with some affecting multiple different enzymes. Associated variants implicate genes that demonstrate diverse liver cell type expression and promote a range of metabolic and liver diseases. These findings provide insight into the pathophysiology of liver and other metabolic diseases that are associated with serum liver enzyme concentrations. Nature Publishing Group UK 2021-02-05 /pmc/articles/PMC7865025/ /pubmed/33547301 http://dx.doi.org/10.1038/s41467-020-20870-1 Text en © The Author(s) 2021, corrected publication 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Chen, Vincent L.
Du, Xiaomeng
Chen, Yanhua
Kuppa, Annapurna
Handelman, Samuel K.
Vohnoutka, Rishel B.
Peyser, Patricia A.
Palmer, Nicholette D.
Bielak, Lawrence F.
Halligan, Brian
Speliotes, Elizabeth K.
Genome-wide association study of serum liver enzymes implicates diverse metabolic and liver pathology
title Genome-wide association study of serum liver enzymes implicates diverse metabolic and liver pathology
title_full Genome-wide association study of serum liver enzymes implicates diverse metabolic and liver pathology
title_fullStr Genome-wide association study of serum liver enzymes implicates diverse metabolic and liver pathology
title_full_unstemmed Genome-wide association study of serum liver enzymes implicates diverse metabolic and liver pathology
title_short Genome-wide association study of serum liver enzymes implicates diverse metabolic and liver pathology
title_sort genome-wide association study of serum liver enzymes implicates diverse metabolic and liver pathology
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865025/
https://www.ncbi.nlm.nih.gov/pubmed/33547301
http://dx.doi.org/10.1038/s41467-020-20870-1
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