IL-22-dependent dysbiosis and mononuclear phagocyte depletion contribute to steroid-resistant gut graft-versus-host disease in mice

Efforts to improve the prognosis of steroid-resistant gut acute graft-versus-host-disease (SR-Gut-aGVHD) have suffered from poor understanding of its pathogenesis. Here we show that the pathogenesis of SR-Gut-aGVHD is associated with reduction of IFN-γ(+) Th/Tc1 cells and preferential expansion of I...

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Detalles Bibliográficos
Autores principales: Song, Qingxiao, Wang, Xiaoning, Wu, Xiwei, Kang, Tae Hyuk, Qin, Hanjun, Zhao, Dongchang, Jenq, Robert R., van den Brink, Marcel R. M., Riggs, Arthur D., Martin, Paul J., Chen, Yuan-Zhong, Zeng, Defu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865028/
https://www.ncbi.nlm.nih.gov/pubmed/33547295
http://dx.doi.org/10.1038/s41467-021-21133-3

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