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Impaired inhibition of return during free-viewing behaviour in patients with schizophrenia

Schizophrenia affects various aspects of cognitive and behavioural functioning. Eye movement abnormalities are commonly observed in patients with schizophrenia (SZs). Here we examined whether such abnormalities reflect an anomaly in inhibition of return (IOR), the mechanism that inhibits orienting t...

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Autores principales: Okada, Ken-ichi, Miura, Kenichiro, Fujimoto, Michiko, Morita, Kentaro, Yoshida, Masatoshi, Yamamori, Hidenaga, Yasuda, Yuka, Iwase, Masao, Inagaki, Mikio, Shinozaki, Takashi, Fujita, Ichiro, Hashimoto, Ryota
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865073/
https://www.ncbi.nlm.nih.gov/pubmed/33547381
http://dx.doi.org/10.1038/s41598-021-82253-w
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author Okada, Ken-ichi
Miura, Kenichiro
Fujimoto, Michiko
Morita, Kentaro
Yoshida, Masatoshi
Yamamori, Hidenaga
Yasuda, Yuka
Iwase, Masao
Inagaki, Mikio
Shinozaki, Takashi
Fujita, Ichiro
Hashimoto, Ryota
author_facet Okada, Ken-ichi
Miura, Kenichiro
Fujimoto, Michiko
Morita, Kentaro
Yoshida, Masatoshi
Yamamori, Hidenaga
Yasuda, Yuka
Iwase, Masao
Inagaki, Mikio
Shinozaki, Takashi
Fujita, Ichiro
Hashimoto, Ryota
author_sort Okada, Ken-ichi
collection PubMed
description Schizophrenia affects various aspects of cognitive and behavioural functioning. Eye movement abnormalities are commonly observed in patients with schizophrenia (SZs). Here we examined whether such abnormalities reflect an anomaly in inhibition of return (IOR), the mechanism that inhibits orienting to previously fixated or attended locations. We analyzed spatiotemporal patterns of eye movement during free-viewing of visual images including natural scenes, geometrical patterns, and pseudorandom noise in SZs and healthy control participants (HCs). SZs made saccades to previously fixated locations more frequently than HCs. The time lapse from the preceding saccade was longer for return saccades than for forward saccades in both SZs and HCs, but the difference was smaller in SZs. SZs explored a smaller area than HCs. Generalized linear mixed-effect model analysis indicated that the frequent return saccades served to confine SZs’ visual exploration to localized regions. The higher probability of return saccades in SZs was related to cognitive decline after disease onset but not to the dose of prescribed antipsychotics. We conclude that SZs exhibited attenuated IOR under free-viewing conditions, which led to restricted scene scanning. IOR attenuation will be a useful clue for detecting impairment in attention/orienting control and accompanying cognitive decline in schizophrenia.
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spelling pubmed-78650732021-02-10 Impaired inhibition of return during free-viewing behaviour in patients with schizophrenia Okada, Ken-ichi Miura, Kenichiro Fujimoto, Michiko Morita, Kentaro Yoshida, Masatoshi Yamamori, Hidenaga Yasuda, Yuka Iwase, Masao Inagaki, Mikio Shinozaki, Takashi Fujita, Ichiro Hashimoto, Ryota Sci Rep Article Schizophrenia affects various aspects of cognitive and behavioural functioning. Eye movement abnormalities are commonly observed in patients with schizophrenia (SZs). Here we examined whether such abnormalities reflect an anomaly in inhibition of return (IOR), the mechanism that inhibits orienting to previously fixated or attended locations. We analyzed spatiotemporal patterns of eye movement during free-viewing of visual images including natural scenes, geometrical patterns, and pseudorandom noise in SZs and healthy control participants (HCs). SZs made saccades to previously fixated locations more frequently than HCs. The time lapse from the preceding saccade was longer for return saccades than for forward saccades in both SZs and HCs, but the difference was smaller in SZs. SZs explored a smaller area than HCs. Generalized linear mixed-effect model analysis indicated that the frequent return saccades served to confine SZs’ visual exploration to localized regions. The higher probability of return saccades in SZs was related to cognitive decline after disease onset but not to the dose of prescribed antipsychotics. We conclude that SZs exhibited attenuated IOR under free-viewing conditions, which led to restricted scene scanning. IOR attenuation will be a useful clue for detecting impairment in attention/orienting control and accompanying cognitive decline in schizophrenia. Nature Publishing Group UK 2021-02-05 /pmc/articles/PMC7865073/ /pubmed/33547381 http://dx.doi.org/10.1038/s41598-021-82253-w Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Okada, Ken-ichi
Miura, Kenichiro
Fujimoto, Michiko
Morita, Kentaro
Yoshida, Masatoshi
Yamamori, Hidenaga
Yasuda, Yuka
Iwase, Masao
Inagaki, Mikio
Shinozaki, Takashi
Fujita, Ichiro
Hashimoto, Ryota
Impaired inhibition of return during free-viewing behaviour in patients with schizophrenia
title Impaired inhibition of return during free-viewing behaviour in patients with schizophrenia
title_full Impaired inhibition of return during free-viewing behaviour in patients with schizophrenia
title_fullStr Impaired inhibition of return during free-viewing behaviour in patients with schizophrenia
title_full_unstemmed Impaired inhibition of return during free-viewing behaviour in patients with schizophrenia
title_short Impaired inhibition of return during free-viewing behaviour in patients with schizophrenia
title_sort impaired inhibition of return during free-viewing behaviour in patients with schizophrenia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865073/
https://www.ncbi.nlm.nih.gov/pubmed/33547381
http://dx.doi.org/10.1038/s41598-021-82253-w
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