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The rDNA Loci—Intersections of Replication, Transcription, and Repair Pathways

Genes encoding ribosomal RNA (rDNA) are essential for cell survival and are particularly sensitive to factors leading to genomic instability. Their repetitive character makes them prone to inappropriate recombinational events arising from collision of transcriptional and replication machineries, res...

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Detalles Bibliográficos
Autores principales: Goffová, Ivana, Fajkus, Jiří
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865372/
https://www.ncbi.nlm.nih.gov/pubmed/33525595
http://dx.doi.org/10.3390/ijms22031302
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author Goffová, Ivana
Fajkus, Jiří
author_facet Goffová, Ivana
Fajkus, Jiří
author_sort Goffová, Ivana
collection PubMed
description Genes encoding ribosomal RNA (rDNA) are essential for cell survival and are particularly sensitive to factors leading to genomic instability. Their repetitive character makes them prone to inappropriate recombinational events arising from collision of transcriptional and replication machineries, resulting in unstable rDNA copy numbers. In this review, we summarize current knowledge on the structure and organization of rDNA, its role in sensing changes in the genome, and its linkage to aging. We also review recent findings on the main factors involved in chromatin assembly and DNA repair in the maintenance of rDNA stability in the model plants Arabidopsis thaliana and the moss Physcomitrella patens, providing a view across the plant evolutionary tree.
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spelling pubmed-78653722021-02-07 The rDNA Loci—Intersections of Replication, Transcription, and Repair Pathways Goffová, Ivana Fajkus, Jiří Int J Mol Sci Review Genes encoding ribosomal RNA (rDNA) are essential for cell survival and are particularly sensitive to factors leading to genomic instability. Their repetitive character makes them prone to inappropriate recombinational events arising from collision of transcriptional and replication machineries, resulting in unstable rDNA copy numbers. In this review, we summarize current knowledge on the structure and organization of rDNA, its role in sensing changes in the genome, and its linkage to aging. We also review recent findings on the main factors involved in chromatin assembly and DNA repair in the maintenance of rDNA stability in the model plants Arabidopsis thaliana and the moss Physcomitrella patens, providing a view across the plant evolutionary tree. MDPI 2021-01-28 /pmc/articles/PMC7865372/ /pubmed/33525595 http://dx.doi.org/10.3390/ijms22031302 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Goffová, Ivana
Fajkus, Jiří
The rDNA Loci—Intersections of Replication, Transcription, and Repair Pathways
title The rDNA Loci—Intersections of Replication, Transcription, and Repair Pathways
title_full The rDNA Loci—Intersections of Replication, Transcription, and Repair Pathways
title_fullStr The rDNA Loci—Intersections of Replication, Transcription, and Repair Pathways
title_full_unstemmed The rDNA Loci—Intersections of Replication, Transcription, and Repair Pathways
title_short The rDNA Loci—Intersections of Replication, Transcription, and Repair Pathways
title_sort rdna loci—intersections of replication, transcription, and repair pathways
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865372/
https://www.ncbi.nlm.nih.gov/pubmed/33525595
http://dx.doi.org/10.3390/ijms22031302
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