Cargando…

The Impact of Environment on Gait Assessment: Considerations from Real-World Gait Analysis in Dementia Subtypes

Laboratory-based gait assessments are indicative of clinical outcomes (e.g., disease identification). Real-world gait may be more sensitive to clinical outcomes, as impairments may be exaggerated in complex environments. This study aims to investigate how different environments (e.g., lab, real worl...

Descripción completa

Detalles Bibliográficos
Autores principales: Mc Ardle, Ríona, Del Din, Silvia, Donaghy, Paul, Galna, Brook, Thomas, Alan J, Rochester, Lynn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865394/
https://www.ncbi.nlm.nih.gov/pubmed/33530508
http://dx.doi.org/10.3390/s21030813
_version_ 1783647835895365632
author Mc Ardle, Ríona
Del Din, Silvia
Donaghy, Paul
Galna, Brook
Thomas, Alan J
Rochester, Lynn
author_facet Mc Ardle, Ríona
Del Din, Silvia
Donaghy, Paul
Galna, Brook
Thomas, Alan J
Rochester, Lynn
author_sort Mc Ardle, Ríona
collection PubMed
description Laboratory-based gait assessments are indicative of clinical outcomes (e.g., disease identification). Real-world gait may be more sensitive to clinical outcomes, as impairments may be exaggerated in complex environments. This study aims to investigate how different environments (e.g., lab, real world) impact gait. Different walking bout lengths in the real world will be considered proxy measures of context. Data collected in different dementia disease subtypes will be analysed as disease-specific gait impairments are reported between these groups. Thirty-two people with cognitive impairment due to Alzheimer’s disease (AD), 28 due to dementia with Lewy bodies (DLB) and 25 controls were recruited. Participants wore a tri-axial accelerometer for six 10 m walks in lab settings, and continuously for seven days in the real world. Fourteen gait characteristics across five domains were measured (i.e., pace, variability, rhythm, asymmetry, postural control). In the lab, the DLB group showed greater step length variability (p = 0.008) compared to AD. Both subtypes demonstrated significant gait impairments (p < 0.01) compared to controls. In the real world, only very short walking bouts (<10 s) demonstrated different gait impairments between subtypes. The context where walking occurs impacts signatures of gait impairment in dementia subtypes. To develop real-world gait assessment as a clinical tool, algorithms and metrics must accommodate for changes in context.
format Online
Article
Text
id pubmed-7865394
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-78653942021-02-07 The Impact of Environment on Gait Assessment: Considerations from Real-World Gait Analysis in Dementia Subtypes Mc Ardle, Ríona Del Din, Silvia Donaghy, Paul Galna, Brook Thomas, Alan J Rochester, Lynn Sensors (Basel) Article Laboratory-based gait assessments are indicative of clinical outcomes (e.g., disease identification). Real-world gait may be more sensitive to clinical outcomes, as impairments may be exaggerated in complex environments. This study aims to investigate how different environments (e.g., lab, real world) impact gait. Different walking bout lengths in the real world will be considered proxy measures of context. Data collected in different dementia disease subtypes will be analysed as disease-specific gait impairments are reported between these groups. Thirty-two people with cognitive impairment due to Alzheimer’s disease (AD), 28 due to dementia with Lewy bodies (DLB) and 25 controls were recruited. Participants wore a tri-axial accelerometer for six 10 m walks in lab settings, and continuously for seven days in the real world. Fourteen gait characteristics across five domains were measured (i.e., pace, variability, rhythm, asymmetry, postural control). In the lab, the DLB group showed greater step length variability (p = 0.008) compared to AD. Both subtypes demonstrated significant gait impairments (p < 0.01) compared to controls. In the real world, only very short walking bouts (<10 s) demonstrated different gait impairments between subtypes. The context where walking occurs impacts signatures of gait impairment in dementia subtypes. To develop real-world gait assessment as a clinical tool, algorithms and metrics must accommodate for changes in context. MDPI 2021-01-26 /pmc/articles/PMC7865394/ /pubmed/33530508 http://dx.doi.org/10.3390/s21030813 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mc Ardle, Ríona
Del Din, Silvia
Donaghy, Paul
Galna, Brook
Thomas, Alan J
Rochester, Lynn
The Impact of Environment on Gait Assessment: Considerations from Real-World Gait Analysis in Dementia Subtypes
title The Impact of Environment on Gait Assessment: Considerations from Real-World Gait Analysis in Dementia Subtypes
title_full The Impact of Environment on Gait Assessment: Considerations from Real-World Gait Analysis in Dementia Subtypes
title_fullStr The Impact of Environment on Gait Assessment: Considerations from Real-World Gait Analysis in Dementia Subtypes
title_full_unstemmed The Impact of Environment on Gait Assessment: Considerations from Real-World Gait Analysis in Dementia Subtypes
title_short The Impact of Environment on Gait Assessment: Considerations from Real-World Gait Analysis in Dementia Subtypes
title_sort impact of environment on gait assessment: considerations from real-world gait analysis in dementia subtypes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865394/
https://www.ncbi.nlm.nih.gov/pubmed/33530508
http://dx.doi.org/10.3390/s21030813
work_keys_str_mv AT mcardleriona theimpactofenvironmentongaitassessmentconsiderationsfromrealworldgaitanalysisindementiasubtypes
AT deldinsilvia theimpactofenvironmentongaitassessmentconsiderationsfromrealworldgaitanalysisindementiasubtypes
AT donaghypaul theimpactofenvironmentongaitassessmentconsiderationsfromrealworldgaitanalysisindementiasubtypes
AT galnabrook theimpactofenvironmentongaitassessmentconsiderationsfromrealworldgaitanalysisindementiasubtypes
AT thomasalanj theimpactofenvironmentongaitassessmentconsiderationsfromrealworldgaitanalysisindementiasubtypes
AT rochesterlynn theimpactofenvironmentongaitassessmentconsiderationsfromrealworldgaitanalysisindementiasubtypes
AT mcardleriona impactofenvironmentongaitassessmentconsiderationsfromrealworldgaitanalysisindementiasubtypes
AT deldinsilvia impactofenvironmentongaitassessmentconsiderationsfromrealworldgaitanalysisindementiasubtypes
AT donaghypaul impactofenvironmentongaitassessmentconsiderationsfromrealworldgaitanalysisindementiasubtypes
AT galnabrook impactofenvironmentongaitassessmentconsiderationsfromrealworldgaitanalysisindementiasubtypes
AT thomasalanj impactofenvironmentongaitassessmentconsiderationsfromrealworldgaitanalysisindementiasubtypes
AT rochesterlynn impactofenvironmentongaitassessmentconsiderationsfromrealworldgaitanalysisindementiasubtypes