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Gut Microbial Signatures in Sporadic and Hereditary Colorectal Cancer

Colorectal cancer (CRC) is the fourth most common cause of cancer-related death and the third most common cancer in the world. Depending on the origin of the mutation, colorectal carcinomas are classified as sporadic or hereditary. Cancers derived from mutations appearing during life, affecting indi...

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Detalles Bibliográficos
Autores principales: Mori, Giorgia, Pasca, Maria Rosalia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865401/
https://www.ncbi.nlm.nih.gov/pubmed/33525662
http://dx.doi.org/10.3390/ijms22031312
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author Mori, Giorgia
Pasca, Maria Rosalia
author_facet Mori, Giorgia
Pasca, Maria Rosalia
author_sort Mori, Giorgia
collection PubMed
description Colorectal cancer (CRC) is the fourth most common cause of cancer-related death and the third most common cancer in the world. Depending on the origin of the mutation, colorectal carcinomas are classified as sporadic or hereditary. Cancers derived from mutations appearing during life, affecting individual cells and their descendants, are called sporadic and account for almost 95% of the CRCs. Less than 5% of CRC cases result from constitutional mutations conferring a very high risk of developing cancer. Screening for hereditary-related cancers is offered to individuals at risk for hereditary CRC, who have either not undergone genetic evaluation or have uncertain genetic test results. In this review, we briefly summarize the main findings on the correlation between sporadic CRC and the gut microbiota, and we specifically focus on the few evidences about the role that gut microorganisms have on the development of CRC hereditary syndromes. The characterization of a gut microbiota associated with an increased risk of developing CRC could have a profound impact for prevention purposes. We also discuss the potential role of the gut microbiota as therapeutic treatment.
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spelling pubmed-78654012021-02-07 Gut Microbial Signatures in Sporadic and Hereditary Colorectal Cancer Mori, Giorgia Pasca, Maria Rosalia Int J Mol Sci Review Colorectal cancer (CRC) is the fourth most common cause of cancer-related death and the third most common cancer in the world. Depending on the origin of the mutation, colorectal carcinomas are classified as sporadic or hereditary. Cancers derived from mutations appearing during life, affecting individual cells and their descendants, are called sporadic and account for almost 95% of the CRCs. Less than 5% of CRC cases result from constitutional mutations conferring a very high risk of developing cancer. Screening for hereditary-related cancers is offered to individuals at risk for hereditary CRC, who have either not undergone genetic evaluation or have uncertain genetic test results. In this review, we briefly summarize the main findings on the correlation between sporadic CRC and the gut microbiota, and we specifically focus on the few evidences about the role that gut microorganisms have on the development of CRC hereditary syndromes. The characterization of a gut microbiota associated with an increased risk of developing CRC could have a profound impact for prevention purposes. We also discuss the potential role of the gut microbiota as therapeutic treatment. MDPI 2021-01-28 /pmc/articles/PMC7865401/ /pubmed/33525662 http://dx.doi.org/10.3390/ijms22031312 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mori, Giorgia
Pasca, Maria Rosalia
Gut Microbial Signatures in Sporadic and Hereditary Colorectal Cancer
title Gut Microbial Signatures in Sporadic and Hereditary Colorectal Cancer
title_full Gut Microbial Signatures in Sporadic and Hereditary Colorectal Cancer
title_fullStr Gut Microbial Signatures in Sporadic and Hereditary Colorectal Cancer
title_full_unstemmed Gut Microbial Signatures in Sporadic and Hereditary Colorectal Cancer
title_short Gut Microbial Signatures in Sporadic and Hereditary Colorectal Cancer
title_sort gut microbial signatures in sporadic and hereditary colorectal cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865401/
https://www.ncbi.nlm.nih.gov/pubmed/33525662
http://dx.doi.org/10.3390/ijms22031312
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