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GYNOCARE Update: Modern Strategies to Improve Diagnosis and Treatment of Rare Gynecologic Tumors—Current Challenges and Future Directions

SIMPLE SUMMARY: More than 50% of all the tumors affecting the female genital tract can be classified as rare and usually have a poor prognosis owing to delayed diagnosis and treatment. Currently, gynecologic cancer research, due to distinct scientific and technological challenges, is lagging behind....

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Autores principales: Di Fiore, Riccardo, Suleiman, Sherif, Ellul, Bridget, O’Toole, Sharon A., Savona-Ventura, Charles, Felix, Ana, Napolioni, Valerio, Conlon, Neil T., Kahramanoglu, Ilker, Azzopardi, Miriam J., Dalmas, Miriam, Calleja, Neville, Brincat, Mark R., Muscat-Baron, Yves, Sabol, Maja, Dimitrievska, Vera, Yordanov, Angel, Vasileva-Slaveva, Mariela, von Brockdorff, Kristelle, Micallef, Rachel A., Kubelac, Paul, Achimas-Cadariu, Patriciu, Vlad, Catalin, Tzortzatou, Olga, Poka, Robert, Giordano, Antonio, Felice, Alex, Reed, Nicholas, Herrington, C. Simon, Faraggi, David, Calleja-Agius, Jean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865420/
https://www.ncbi.nlm.nih.gov/pubmed/33514073
http://dx.doi.org/10.3390/cancers13030493
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author Di Fiore, Riccardo
Suleiman, Sherif
Ellul, Bridget
O’Toole, Sharon A.
Savona-Ventura, Charles
Felix, Ana
Napolioni, Valerio
Conlon, Neil T.
Kahramanoglu, Ilker
Azzopardi, Miriam J.
Dalmas, Miriam
Calleja, Neville
Brincat, Mark R.
Muscat-Baron, Yves
Sabol, Maja
Dimitrievska, Vera
Yordanov, Angel
Vasileva-Slaveva, Mariela
von Brockdorff, Kristelle
Micallef, Rachel A.
Kubelac, Paul
Achimas-Cadariu, Patriciu
Vlad, Catalin
Tzortzatou, Olga
Poka, Robert
Giordano, Antonio
Felice, Alex
Reed, Nicholas
Herrington, C. Simon
Faraggi, David
Calleja-Agius, Jean
author_facet Di Fiore, Riccardo
Suleiman, Sherif
Ellul, Bridget
O’Toole, Sharon A.
Savona-Ventura, Charles
Felix, Ana
Napolioni, Valerio
Conlon, Neil T.
Kahramanoglu, Ilker
Azzopardi, Miriam J.
Dalmas, Miriam
Calleja, Neville
Brincat, Mark R.
Muscat-Baron, Yves
Sabol, Maja
Dimitrievska, Vera
Yordanov, Angel
Vasileva-Slaveva, Mariela
von Brockdorff, Kristelle
Micallef, Rachel A.
Kubelac, Paul
Achimas-Cadariu, Patriciu
Vlad, Catalin
Tzortzatou, Olga
Poka, Robert
Giordano, Antonio
Felice, Alex
Reed, Nicholas
Herrington, C. Simon
Faraggi, David
Calleja-Agius, Jean
author_sort Di Fiore, Riccardo
collection PubMed
description SIMPLE SUMMARY: More than 50% of all the tumors affecting the female genital tract can be classified as rare and usually have a poor prognosis owing to delayed diagnosis and treatment. Currently, gynecologic cancer research, due to distinct scientific and technological challenges, is lagging behind. Moreover, the overall efforts for addressing these challenges are fragmented across different countries. The European Network for Gynecological Rare Cancer Research: GYNOCARE aims to address these challenges by creating a unique network between key stakeholders covering distinct domains from basic research to cure. GYNOCARE is part of a European Collaboration in Science and Technology (COST) with the aim to focus on the development of new approaches to improve the diagnosis and treatment of rare gynecological tumors. Here, we provide a brief overview describing the goals of this COST Action and its future challenges with the aim to continue fighting against this rare cancer. ABSTRACT: More than 50% of all gynecologic tumors can be classified as rare (defined as an incidence of ≤6 per 100,000 women) and usually have a poor prognosis owing to delayed diagnosis and treatment. In contrast to almost all other common solid tumors, the treatment of rare gynecologic tumors (RGT) is often based on expert opinion, retrospective studies, or extrapolation from other tumor sites with similar histology, leading to difficulty in developing guidelines for clinical practice. Currently, gynecologic cancer research, due to distinct scientific and technological challenges, is lagging behind. Moreover, the overall efforts for addressing these challenges are fragmented across different European countries and indeed, worldwide. The GYNOCARE, COST Action CA18117 (European Network for Gynecological Rare Cancer Research) programme aims to address these challenges through the creation of a unique network between key stakeholders covering distinct domains from concept to cure: basic research on RGT, biobanking, bridging with industry, and setting up the legal and regulatory requirements for international innovative clinical trials. On this basis, members of this COST Action, (Working Group 1, “Basic and Translational Research on Rare Gynecological Cancer”) have decided to focus their future efforts on the development of new approaches to improve the diagnosis and treatment of RGT. Here, we provide a brief overview of the current state-of-the-art and describe the goals of this COST Action and its future challenges with the aim to stimulate discussion and promote synergy across scientists engaged in the fight against this rare cancer worldwide.
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spelling pubmed-78654202021-02-07 GYNOCARE Update: Modern Strategies to Improve Diagnosis and Treatment of Rare Gynecologic Tumors—Current Challenges and Future Directions Di Fiore, Riccardo Suleiman, Sherif Ellul, Bridget O’Toole, Sharon A. Savona-Ventura, Charles Felix, Ana Napolioni, Valerio Conlon, Neil T. Kahramanoglu, Ilker Azzopardi, Miriam J. Dalmas, Miriam Calleja, Neville Brincat, Mark R. Muscat-Baron, Yves Sabol, Maja Dimitrievska, Vera Yordanov, Angel Vasileva-Slaveva, Mariela von Brockdorff, Kristelle Micallef, Rachel A. Kubelac, Paul Achimas-Cadariu, Patriciu Vlad, Catalin Tzortzatou, Olga Poka, Robert Giordano, Antonio Felice, Alex Reed, Nicholas Herrington, C. Simon Faraggi, David Calleja-Agius, Jean Cancers (Basel) Article SIMPLE SUMMARY: More than 50% of all the tumors affecting the female genital tract can be classified as rare and usually have a poor prognosis owing to delayed diagnosis and treatment. Currently, gynecologic cancer research, due to distinct scientific and technological challenges, is lagging behind. Moreover, the overall efforts for addressing these challenges are fragmented across different countries. The European Network for Gynecological Rare Cancer Research: GYNOCARE aims to address these challenges by creating a unique network between key stakeholders covering distinct domains from basic research to cure. GYNOCARE is part of a European Collaboration in Science and Technology (COST) with the aim to focus on the development of new approaches to improve the diagnosis and treatment of rare gynecological tumors. Here, we provide a brief overview describing the goals of this COST Action and its future challenges with the aim to continue fighting against this rare cancer. ABSTRACT: More than 50% of all gynecologic tumors can be classified as rare (defined as an incidence of ≤6 per 100,000 women) and usually have a poor prognosis owing to delayed diagnosis and treatment. In contrast to almost all other common solid tumors, the treatment of rare gynecologic tumors (RGT) is often based on expert opinion, retrospective studies, or extrapolation from other tumor sites with similar histology, leading to difficulty in developing guidelines for clinical practice. Currently, gynecologic cancer research, due to distinct scientific and technological challenges, is lagging behind. Moreover, the overall efforts for addressing these challenges are fragmented across different European countries and indeed, worldwide. The GYNOCARE, COST Action CA18117 (European Network for Gynecological Rare Cancer Research) programme aims to address these challenges through the creation of a unique network between key stakeholders covering distinct domains from concept to cure: basic research on RGT, biobanking, bridging with industry, and setting up the legal and regulatory requirements for international innovative clinical trials. On this basis, members of this COST Action, (Working Group 1, “Basic and Translational Research on Rare Gynecological Cancer”) have decided to focus their future efforts on the development of new approaches to improve the diagnosis and treatment of RGT. Here, we provide a brief overview of the current state-of-the-art and describe the goals of this COST Action and its future challenges with the aim to stimulate discussion and promote synergy across scientists engaged in the fight against this rare cancer worldwide. MDPI 2021-01-27 /pmc/articles/PMC7865420/ /pubmed/33514073 http://dx.doi.org/10.3390/cancers13030493 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Di Fiore, Riccardo
Suleiman, Sherif
Ellul, Bridget
O’Toole, Sharon A.
Savona-Ventura, Charles
Felix, Ana
Napolioni, Valerio
Conlon, Neil T.
Kahramanoglu, Ilker
Azzopardi, Miriam J.
Dalmas, Miriam
Calleja, Neville
Brincat, Mark R.
Muscat-Baron, Yves
Sabol, Maja
Dimitrievska, Vera
Yordanov, Angel
Vasileva-Slaveva, Mariela
von Brockdorff, Kristelle
Micallef, Rachel A.
Kubelac, Paul
Achimas-Cadariu, Patriciu
Vlad, Catalin
Tzortzatou, Olga
Poka, Robert
Giordano, Antonio
Felice, Alex
Reed, Nicholas
Herrington, C. Simon
Faraggi, David
Calleja-Agius, Jean
GYNOCARE Update: Modern Strategies to Improve Diagnosis and Treatment of Rare Gynecologic Tumors—Current Challenges and Future Directions
title GYNOCARE Update: Modern Strategies to Improve Diagnosis and Treatment of Rare Gynecologic Tumors—Current Challenges and Future Directions
title_full GYNOCARE Update: Modern Strategies to Improve Diagnosis and Treatment of Rare Gynecologic Tumors—Current Challenges and Future Directions
title_fullStr GYNOCARE Update: Modern Strategies to Improve Diagnosis and Treatment of Rare Gynecologic Tumors—Current Challenges and Future Directions
title_full_unstemmed GYNOCARE Update: Modern Strategies to Improve Diagnosis and Treatment of Rare Gynecologic Tumors—Current Challenges and Future Directions
title_short GYNOCARE Update: Modern Strategies to Improve Diagnosis and Treatment of Rare Gynecologic Tumors—Current Challenges and Future Directions
title_sort gynocare update: modern strategies to improve diagnosis and treatment of rare gynecologic tumors—current challenges and future directions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865420/
https://www.ncbi.nlm.nih.gov/pubmed/33514073
http://dx.doi.org/10.3390/cancers13030493
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