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Association of Exercise-Based Cardiac Rehabilitation with Progression of Paroxysmal to Sustained Atrial Fibrillation

Progression of atrial fibrillation (AF) is associated with worsened prognosis for cardiovascular events and mortality. Exercise-based-cardiac rehabilitation programmes have shown preliminary promise for primary and secondary prevention of AF. Yet, such interventions are typically reserved for patien...

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Autores principales: Buckley, Benjamin J. R., Harrison, Stephanie L., Fazio-Eynullayeva, Elnara, Underhill, Paula, Lane, Deirdre A., Thijssen, Dick H. J., Lip, Gregory Y. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865453/
https://www.ncbi.nlm.nih.gov/pubmed/33498648
http://dx.doi.org/10.3390/jcm10030435
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author Buckley, Benjamin J. R.
Harrison, Stephanie L.
Fazio-Eynullayeva, Elnara
Underhill, Paula
Lane, Deirdre A.
Thijssen, Dick H. J.
Lip, Gregory Y. H.
author_facet Buckley, Benjamin J. R.
Harrison, Stephanie L.
Fazio-Eynullayeva, Elnara
Underhill, Paula
Lane, Deirdre A.
Thijssen, Dick H. J.
Lip, Gregory Y. H.
author_sort Buckley, Benjamin J. R.
collection PubMed
description Progression of atrial fibrillation (AF) is associated with worsened prognosis for cardiovascular events and mortality. Exercise-based-cardiac rehabilitation programmes have shown preliminary promise for primary and secondary prevention of AF. Yet, such interventions are typically reserved for patients with acute coronary syndrome or undergoing revascularization. Using a retrospective cohort design, the present study investigated the association of exercise-based cardiac rehabilitation on the progression of paroxysmal to sustained AF, compared to propensity-matched controls. Patients with a diagnosis of paroxysmal AF were compared between those with and without an electronic medical record of exercise-based cardiac rehabilitation within 6-months of diagnosis. Using cox regression models, we ascertained odds of 2-year incidence for AF progression. This cohort of 9808 patients with paroxysmal AF demonstrated that exercise-based cardiac rehabilitation was associated with 26% lower odds of AF progression (odds ratio 0.74, 95% CI 0.66–0.83) compared to propensity-matched controls. This beneficial effect seemed to vary across patient subgroups. In conclusion, findings revealed that exercise-based cardiac rehabilitation was associated with significantly lower odds of progression from paroxysmal to sustained AF at 2-years follow-up compared to propensity-matched controls.
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spelling pubmed-78654532021-02-07 Association of Exercise-Based Cardiac Rehabilitation with Progression of Paroxysmal to Sustained Atrial Fibrillation Buckley, Benjamin J. R. Harrison, Stephanie L. Fazio-Eynullayeva, Elnara Underhill, Paula Lane, Deirdre A. Thijssen, Dick H. J. Lip, Gregory Y. H. J Clin Med Brief Report Progression of atrial fibrillation (AF) is associated with worsened prognosis for cardiovascular events and mortality. Exercise-based-cardiac rehabilitation programmes have shown preliminary promise for primary and secondary prevention of AF. Yet, such interventions are typically reserved for patients with acute coronary syndrome or undergoing revascularization. Using a retrospective cohort design, the present study investigated the association of exercise-based cardiac rehabilitation on the progression of paroxysmal to sustained AF, compared to propensity-matched controls. Patients with a diagnosis of paroxysmal AF were compared between those with and without an electronic medical record of exercise-based cardiac rehabilitation within 6-months of diagnosis. Using cox regression models, we ascertained odds of 2-year incidence for AF progression. This cohort of 9808 patients with paroxysmal AF demonstrated that exercise-based cardiac rehabilitation was associated with 26% lower odds of AF progression (odds ratio 0.74, 95% CI 0.66–0.83) compared to propensity-matched controls. This beneficial effect seemed to vary across patient subgroups. In conclusion, findings revealed that exercise-based cardiac rehabilitation was associated with significantly lower odds of progression from paroxysmal to sustained AF at 2-years follow-up compared to propensity-matched controls. MDPI 2021-01-23 /pmc/articles/PMC7865453/ /pubmed/33498648 http://dx.doi.org/10.3390/jcm10030435 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Buckley, Benjamin J. R.
Harrison, Stephanie L.
Fazio-Eynullayeva, Elnara
Underhill, Paula
Lane, Deirdre A.
Thijssen, Dick H. J.
Lip, Gregory Y. H.
Association of Exercise-Based Cardiac Rehabilitation with Progression of Paroxysmal to Sustained Atrial Fibrillation
title Association of Exercise-Based Cardiac Rehabilitation with Progression of Paroxysmal to Sustained Atrial Fibrillation
title_full Association of Exercise-Based Cardiac Rehabilitation with Progression of Paroxysmal to Sustained Atrial Fibrillation
title_fullStr Association of Exercise-Based Cardiac Rehabilitation with Progression of Paroxysmal to Sustained Atrial Fibrillation
title_full_unstemmed Association of Exercise-Based Cardiac Rehabilitation with Progression of Paroxysmal to Sustained Atrial Fibrillation
title_short Association of Exercise-Based Cardiac Rehabilitation with Progression of Paroxysmal to Sustained Atrial Fibrillation
title_sort association of exercise-based cardiac rehabilitation with progression of paroxysmal to sustained atrial fibrillation
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865453/
https://www.ncbi.nlm.nih.gov/pubmed/33498648
http://dx.doi.org/10.3390/jcm10030435
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