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Association of Exercise-Based Cardiac Rehabilitation with Progression of Paroxysmal to Sustained Atrial Fibrillation
Progression of atrial fibrillation (AF) is associated with worsened prognosis for cardiovascular events and mortality. Exercise-based-cardiac rehabilitation programmes have shown preliminary promise for primary and secondary prevention of AF. Yet, such interventions are typically reserved for patien...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865453/ https://www.ncbi.nlm.nih.gov/pubmed/33498648 http://dx.doi.org/10.3390/jcm10030435 |
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author | Buckley, Benjamin J. R. Harrison, Stephanie L. Fazio-Eynullayeva, Elnara Underhill, Paula Lane, Deirdre A. Thijssen, Dick H. J. Lip, Gregory Y. H. |
author_facet | Buckley, Benjamin J. R. Harrison, Stephanie L. Fazio-Eynullayeva, Elnara Underhill, Paula Lane, Deirdre A. Thijssen, Dick H. J. Lip, Gregory Y. H. |
author_sort | Buckley, Benjamin J. R. |
collection | PubMed |
description | Progression of atrial fibrillation (AF) is associated with worsened prognosis for cardiovascular events and mortality. Exercise-based-cardiac rehabilitation programmes have shown preliminary promise for primary and secondary prevention of AF. Yet, such interventions are typically reserved for patients with acute coronary syndrome or undergoing revascularization. Using a retrospective cohort design, the present study investigated the association of exercise-based cardiac rehabilitation on the progression of paroxysmal to sustained AF, compared to propensity-matched controls. Patients with a diagnosis of paroxysmal AF were compared between those with and without an electronic medical record of exercise-based cardiac rehabilitation within 6-months of diagnosis. Using cox regression models, we ascertained odds of 2-year incidence for AF progression. This cohort of 9808 patients with paroxysmal AF demonstrated that exercise-based cardiac rehabilitation was associated with 26% lower odds of AF progression (odds ratio 0.74, 95% CI 0.66–0.83) compared to propensity-matched controls. This beneficial effect seemed to vary across patient subgroups. In conclusion, findings revealed that exercise-based cardiac rehabilitation was associated with significantly lower odds of progression from paroxysmal to sustained AF at 2-years follow-up compared to propensity-matched controls. |
format | Online Article Text |
id | pubmed-7865453 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-78654532021-02-07 Association of Exercise-Based Cardiac Rehabilitation with Progression of Paroxysmal to Sustained Atrial Fibrillation Buckley, Benjamin J. R. Harrison, Stephanie L. Fazio-Eynullayeva, Elnara Underhill, Paula Lane, Deirdre A. Thijssen, Dick H. J. Lip, Gregory Y. H. J Clin Med Brief Report Progression of atrial fibrillation (AF) is associated with worsened prognosis for cardiovascular events and mortality. Exercise-based-cardiac rehabilitation programmes have shown preliminary promise for primary and secondary prevention of AF. Yet, such interventions are typically reserved for patients with acute coronary syndrome or undergoing revascularization. Using a retrospective cohort design, the present study investigated the association of exercise-based cardiac rehabilitation on the progression of paroxysmal to sustained AF, compared to propensity-matched controls. Patients with a diagnosis of paroxysmal AF were compared between those with and without an electronic medical record of exercise-based cardiac rehabilitation within 6-months of diagnosis. Using cox regression models, we ascertained odds of 2-year incidence for AF progression. This cohort of 9808 patients with paroxysmal AF demonstrated that exercise-based cardiac rehabilitation was associated with 26% lower odds of AF progression (odds ratio 0.74, 95% CI 0.66–0.83) compared to propensity-matched controls. This beneficial effect seemed to vary across patient subgroups. In conclusion, findings revealed that exercise-based cardiac rehabilitation was associated with significantly lower odds of progression from paroxysmal to sustained AF at 2-years follow-up compared to propensity-matched controls. MDPI 2021-01-23 /pmc/articles/PMC7865453/ /pubmed/33498648 http://dx.doi.org/10.3390/jcm10030435 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Brief Report Buckley, Benjamin J. R. Harrison, Stephanie L. Fazio-Eynullayeva, Elnara Underhill, Paula Lane, Deirdre A. Thijssen, Dick H. J. Lip, Gregory Y. H. Association of Exercise-Based Cardiac Rehabilitation with Progression of Paroxysmal to Sustained Atrial Fibrillation |
title | Association of Exercise-Based Cardiac Rehabilitation with Progression of Paroxysmal to Sustained Atrial Fibrillation |
title_full | Association of Exercise-Based Cardiac Rehabilitation with Progression of Paroxysmal to Sustained Atrial Fibrillation |
title_fullStr | Association of Exercise-Based Cardiac Rehabilitation with Progression of Paroxysmal to Sustained Atrial Fibrillation |
title_full_unstemmed | Association of Exercise-Based Cardiac Rehabilitation with Progression of Paroxysmal to Sustained Atrial Fibrillation |
title_short | Association of Exercise-Based Cardiac Rehabilitation with Progression of Paroxysmal to Sustained Atrial Fibrillation |
title_sort | association of exercise-based cardiac rehabilitation with progression of paroxysmal to sustained atrial fibrillation |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865453/ https://www.ncbi.nlm.nih.gov/pubmed/33498648 http://dx.doi.org/10.3390/jcm10030435 |
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