Induction of Cytokines by Nucleic Acid Nanoparticles (NANPs) Depends on the Type of Delivery Carrier

Recent insights into the immunostimulatory properties of nucleic acid nanoparticles (NANPs) have demonstrated that variations in the shape, size, and composition lead to distinct patterns in their immunostimulatory properties. While most of these studies have used a single lipid-based carrier to all...

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Autores principales: Avila, Yelixza I., Chandler, Morgan, Cedrone, Edward, Newton, Hannah S., Richardson, Melina, Xu, Jie, Clogston, Jeffrey D., Liptrott, Neill J., Afonin, Kirill A., Dobrovolskaia, Marina A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865455/
https://www.ncbi.nlm.nih.gov/pubmed/33513786
http://dx.doi.org/10.3390/molecules26030652
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author Avila, Yelixza I.
Chandler, Morgan
Cedrone, Edward
Newton, Hannah S.
Richardson, Melina
Xu, Jie
Clogston, Jeffrey D.
Liptrott, Neill J.
Afonin, Kirill A.
Dobrovolskaia, Marina A.
author_facet Avila, Yelixza I.
Chandler, Morgan
Cedrone, Edward
Newton, Hannah S.
Richardson, Melina
Xu, Jie
Clogston, Jeffrey D.
Liptrott, Neill J.
Afonin, Kirill A.
Dobrovolskaia, Marina A.
author_sort Avila, Yelixza I.
collection PubMed
description Recent insights into the immunostimulatory properties of nucleic acid nanoparticles (NANPs) have demonstrated that variations in the shape, size, and composition lead to distinct patterns in their immunostimulatory properties. While most of these studies have used a single lipid-based carrier to allow for NANPs’ intracellular delivery, it is now apparent that the platform for delivery, which has historically been a hurdle for therapeutic nucleic acids, is an additional means to tailoring NANP immunorecognition. Here, the use of dendrimers for the delivery of NANPs is compared to the lipid-based platform and the differences in resulting cytokine induction are presented.
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spelling pubmed-78654552021-02-07 Induction of Cytokines by Nucleic Acid Nanoparticles (NANPs) Depends on the Type of Delivery Carrier Avila, Yelixza I. Chandler, Morgan Cedrone, Edward Newton, Hannah S. Richardson, Melina Xu, Jie Clogston, Jeffrey D. Liptrott, Neill J. Afonin, Kirill A. Dobrovolskaia, Marina A. Molecules Article Recent insights into the immunostimulatory properties of nucleic acid nanoparticles (NANPs) have demonstrated that variations in the shape, size, and composition lead to distinct patterns in their immunostimulatory properties. While most of these studies have used a single lipid-based carrier to allow for NANPs’ intracellular delivery, it is now apparent that the platform for delivery, which has historically been a hurdle for therapeutic nucleic acids, is an additional means to tailoring NANP immunorecognition. Here, the use of dendrimers for the delivery of NANPs is compared to the lipid-based platform and the differences in resulting cytokine induction are presented. MDPI 2021-01-27 /pmc/articles/PMC7865455/ /pubmed/33513786 http://dx.doi.org/10.3390/molecules26030652 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Avila, Yelixza I.
Chandler, Morgan
Cedrone, Edward
Newton, Hannah S.
Richardson, Melina
Xu, Jie
Clogston, Jeffrey D.
Liptrott, Neill J.
Afonin, Kirill A.
Dobrovolskaia, Marina A.
Induction of Cytokines by Nucleic Acid Nanoparticles (NANPs) Depends on the Type of Delivery Carrier
title Induction of Cytokines by Nucleic Acid Nanoparticles (NANPs) Depends on the Type of Delivery Carrier
title_full Induction of Cytokines by Nucleic Acid Nanoparticles (NANPs) Depends on the Type of Delivery Carrier
title_fullStr Induction of Cytokines by Nucleic Acid Nanoparticles (NANPs) Depends on the Type of Delivery Carrier
title_full_unstemmed Induction of Cytokines by Nucleic Acid Nanoparticles (NANPs) Depends on the Type of Delivery Carrier
title_short Induction of Cytokines by Nucleic Acid Nanoparticles (NANPs) Depends on the Type of Delivery Carrier
title_sort induction of cytokines by nucleic acid nanoparticles (nanps) depends on the type of delivery carrier
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865455/
https://www.ncbi.nlm.nih.gov/pubmed/33513786
http://dx.doi.org/10.3390/molecules26030652
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