Cargando…

The Interactions of DNA Repair, Telomere Homeostasis, and p53 Mutational Status in Solid Cancers: Risk, Prognosis, and Prediction

SIMPLE SUMMARY: p53 is a nuclear transcription factor with a pro-apoptotic function. Somatic mutations in this gene represent one of the most critical events in human carcinogenesis. The disruption of genomic integrity due to the accumulation of various kinds of DNA damage, deficient DNA repair capa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vodicka, Pavel, Andera, Ladislav, Opattova, Alena, Vodickova, Ludmila
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865496/ https://www.ncbi.nlm.nih.gov/pubmed/33513745 http://dx.doi.org/10.3390/cancers13030479

Ejemplares similares

MiR-140 leads to MRE11 downregulation and ameliorates oxaliplatin treatment and therapy response in colorectal cancer patients
por: Horak, Josef, et al.
Publicado: (2022)

DNA Mismatch Repair Gene Variants in Sporadic Solid Cancers
por: Caja, Fabian, et al.
Publicado: (2020)

Oxidative Damage in Sporadic Colorectal Cancer: Molecular Mapping of Base Excision Repair Glycosylases in Colorectal Cancer Patients
por: Vodicka, Pavel, et al.
Publicado: (2020)

DNA Repair and Ovarian Carcinogenesis: Impact on Risk, Prognosis and Therapy Outcome
por: Tomasova, Kristyna, et al.
Publicado: (2020)

Editorial: Current understanding of genomic and chromosomal instabilities in solid malignancies
por: Vodicka, Pavel, et al.
Publicado: (2023)

Oxidative Damage in Sporadic Colorectal Cancer: Molecular Mapping of Base Excision Repair Glycosylases MUTYH and hOGG1 in Colorectal Cancer Patients
por: Kavec, Miriam J., et al.
Publicado: (2022)

TElomeric repeat-containing RNA (TERRA): Physiological functions and relevance in cancer
por: Kroupa, Michal, et al.
Publicado: (2022)

Relationship of telomere length in colorectal cancer patients with cancer phenotype and patient prognosis
por: Kroupa, Michal, et al.
Publicado: (2019)

MUC13-miRNA-4647 axis in colorectal cancer: Prospects to identifications of risk factors and clinical outcomes
por: Sojka, Ladislav, et al.
Publicado: (2022)

Monitoring of telomere dynamics in peripheral blood leukocytes in relation to colorectal cancer patients’ outcomes
por: Tomasova, Kristyna, et al.
Publicado: (2022)

Genetic Susceptibility in Understanding of Pancreatic Ductal Adenocarcinoma Risk: A Decade-Long Effort of the PANDORA Consortium
por: Vodickova, Ludmila, et al.
Publicado: (2022)

Effect of occupational exposure to cytostatics and nucleotide excision repair polymorphism on chromosomal aberrations frequency
por: Mušák, L'udovít, et al.
Publicado: (2009)

The dynamics of telomere length in primary and metastatic colorectal cancer lesions
por: Kroupa, Michal, et al.
Publicado: (2023)

DNA Repair Gene Polymorphisms and Chromosomal Aberrations in Exposed Populations
por: Niazi, Yasmeen, et al.
Publicado: (2021)

Genotype and Haplotype Analyses of TP53 Gene in Breast Cancer Patients: Association with Risk and Clinical Outcomes
por: Vymetalkova, Veronika, et al.
Publicado: (2015)

DNA damage-induced regulatory interplay between DAXX, p53, ATM kinase and Wip1 phosphatase
por: Brazina, Jan, et al.
Publicado: (2015)

Cytogenetic markers, DNA single-strand breaks, urinary metabolites, and DNA repair rates in styrene-exposed lamination workers.
por: Vodicka, Pavel, et al.
Publicado: (2004)

A novel c. 204 Ile68Met germline variant in exon 2 of the mutL homolog 1 gene in a colorectal cancer patient
por: VODICKA, PAVEL, et al.
Publicado: (2015)

Analysis of MicroRNA Expression Changes During the Course of Therapy In Rectal Cancer Patients
por: Cervena, Klara, et al.
Publicado: (2021)

Biallelic mutations in WRAP53 result in dysfunctional telomeres, Cajal bodies and DNA repair, thereby causing Hoyeraal–Hreidarsson syndrome
por: Bergstrand, Sofie, et al.
Publicado: (2020)

Complex molecular profile of DNA repair genes in epithelial ovarian carcinoma patients with different sensitivity to platinum-based therapy
por: Seborova, Karolina, et al.
Publicado: (2022)

BH3 Mimetics in Hematologic Malignancies
por: Klener, Pavel, et al.
Publicado: (2021)

Telomere status in chronic lymphocytic leukemia with TP53 disruption
por: Guièze, Romain, et al.
Publicado: (2016)

lncRNAs in Non-Malignant Tissue Have Prognostic Value in Colorectal Cancer
por: Thiele, Jana-Aletta, et al.
Publicado: (2018)

Comparison of chromosomal aberrations frequency and polymorphism of GSTs genes in workers occupationally exposed to cytostatics or anaesthetics
por: Mušák, Ľudovít, et al.
Publicado: (2009)

Do GST Polymorphisms Modulate the Frequency of Chromosomal Aberrations in Healthy Subjects?
por: Vodicka, Pavel, et al.
Publicado: (2009)

The Presence of Telomere Fusion in Sporadic Colon Cancer Independently of Disease Stage, TP53/KRAS Mutation Status, Mean Telomere Length, and Telomerase Activity
por: Tanaka, Hiromi, et al.
Publicado: (2014)

Double-strand break repair and colorectal cancer: gene variants within 3′ UTRs and microRNAs binding as modulators of cancer risk and clinical outcome
por: Naccarati, Alessio, et al.
Publicado: (2015)

Telomere Homeostasis: Interplay with Magnesium
por: Maguire, Donogh, et al.
Publicado: (2018)

Collapse of Telomere Homeostasis in Hematopoietic Cells Caused by Heterozygous Mutations in Telomerase Genes
por: Aubert, Geraldine, et al.
Publicado: (2012)

The Guardian of the Genome Revisited: p53 Downregulates Genes Required for Telomere Maintenance, DNA Repair, and Centromere Structure
por: Toufektchan, Eléonore, et al.
Publicado: (2018)

Significance of TP53 Mutational Status-Associated Signature in the Progression and Prognosis of Endometrial Carcinoma
por: Chen, Ying, et al.
Publicado: (2022)

Non-Coding Polymorphisms in Nucleotide Binding Domain 1 in ABCC1 Gene Associate with Transcript Level and Survival of Patients with Breast Cancer
por: Kunická, Tereza, et al.
Publicado: (2014)

Discovery of Long Non-Coding RNA MALAT1 Amplification in Precancerous Colorectal Lesions
por: Siskova, Anna, et al.
Publicado: (2022)

A gene-wide investigation on polymorphisms in the taste receptor 2R14 (TAS2R14) and susceptibility to colorectal cancer
por: Campa, Daniele, et al.
Publicado: (2010)

Single Nucleotide Polymorphisms within Interferon Signaling Pathway Genes Are Associated with Colorectal Cancer Susceptibility and Survival
por: Lu, Shun, et al.
Publicado: (2014)

Distant Metastasis in Colorectal Cancer Patients—Do We Have New Predicting Clinicopathological and Molecular Biomarkers? A Comprehensive Review
por: Filip, Stanislav, et al.
Publicado: (2020)

Mutational analysis of driver genes defines the colorectal adenoma: in situ carcinoma transition
por: Jungwirth, Jiri, et al.
Publicado: (2022)

Exercise-induced mitochondrial p53 repairs mtDNA mutations in mutator mice
por: Safdar, Adeel, et al.
Publicado: (2016)

Author Correction: Mutational analysis of driver genes defines the colorectal adenoma: in situ carcinoma transition
por: Jungwirth, Jiri, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_jrk5rl94jblrur1oeb6h69so4n