Site-Specific Dual-Labeling of a VHH with a Chelator and a Photosensitizer for Nuclear Imaging and Targeted Photodynamic Therapy of EGFR-Positive Tumors

SIMPLE SUMMARY: Variable domains of heavy chain only antibodies are small proteins that can be used for tumor imaging and therapy upon conjugation of functional groups. As frequently used random conjugation techniques can decrease binding to the target of interest, site-specific conjugation of these...

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Autores principales: Renard, Emma, Collado Camps, Estel, Canovas, Coline, Kip, Annemarie, Gotthardt, Martin, Rijpkema, Mark, Denat, Franck, Goncalves, Victor, van Lith, Sanne A. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865570/
https://www.ncbi.nlm.nih.gov/pubmed/33498707
http://dx.doi.org/10.3390/cancers13030428

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