Cargando…

Zoledronate Causes a Systemic Shift of Macrophage Polarization towards M1 In Vivo

Background: Immunomodulatory properties of bisphosphonates (BP) are suggested to contribute to the development of medication-associated osteonecrosis of the jaw (MRONJ). Furthermore, bisphosphonate-derived immune modulation might contribute to the anti-metastatic effect observed in breast cancer pat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Weber, Manuel, Homm, Andi, Müller, Stefan, Frey, Silke, Amann, Kerstin, Ries, Jutta, Geppert, Carol, Preidl, Raimund, Möst, Tobias, Kämmerer, Peer W., Kesting, Marco, Wehrhan, Falk
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865688/ https://www.ncbi.nlm.nih.gov/pubmed/33525753 http://dx.doi.org/10.3390/ijms22031323

Ejemplares similares

Alterations in macrophage polarization in the craniofacial and extracranial skeleton after zoledronate application and surgical interventions – an in vivo experiment
por: Struckmeier, Ann-Kristin, et al.
Publicado: (2023)

Osteoclastic expression of higher-level regulators NFATc1 and BCL6 in medication-related osteonecrosis of the jaw secondary to bisphosphonate therapy: a comparison with osteoradionecrosis and osteomyelitis
por: Wehrhan, Falk, et al.
Publicado: (2019)

Galectin 3 expression in regional lymph nodes and lymph node metastases of oral squamous cell carcinomas
por: Wehrhan, Falk, et al.
Publicado: (2018)

Increased malignancy of oral squamous cell carcinomas (oscc) is associated with macrophage polarization in regional lymph nodes – an immunohistochemical study
por: Wehrhan, Falk, et al.
Publicado: (2014)

Craniofacial Osteosarcoma—Pilot Study on the Expression of Osteobiologic Characteristics and Hypothesis on Metastasis
por: Weber, Manuel, et al.
Publicado: (2020)

Galectin 3 expression in primary oral squamous cell carcinomas
por: Weber, Manuel, et al.
Publicado: (2017)

Osteoclast profile of medication-related osteonecrosis of the jaw secondary to bisphosphonate therapy: a comparison with osteoradionecrosis and osteomyelitis
por: Gross, Christian, et al.
Publicado: (2017)

PD-L1 expression in tumor tissue and peripheral blood of patients with oral squamous cell carcinoma
por: Weber, Manuel, et al.
Publicado: (2017)

Importance of the PD-1/PD-L1 Axis for Malignant Transformation and Risk Assessment of Oral Leukoplakia
por: Ries, Jutta, et al.
Publicado: (2021)

Malignant transformation of oral leukoplakia is associated with macrophage polarization
por: Weber, Manuel, et al.
Publicado: (2020)

Recipient bed perfusion as a predictor for postoperative complications in irradiated patients with microvascular free tissue transfer of the head and neck area: a clinical analysis of 191 microvascular free flaps
por: Foerster, Yannick, et al.
Publicado: (2022)

The Special Developmental Biology of Craniofacial Tissues Enables the Understanding of Oral and Maxillofacial Physiology and Diseases
por: Weber, Manuel, et al.
Publicado: (2021)

Prognostic significance of PD‐L2 expression in patients with oral squamous cell carcinoma—A comparison to the PD‐L1 expression profile
por: Weber, Manuel, et al.
Publicado: (2019)

Postoperative Changes in Systemic Immune Tolerance Following Major Oncologic versus Minor Maxillofacial Surgery
por: Trumet, Leah, et al.
Publicado: (2023)

The Immune Checkpoint Receptor CD96: A Local and Systemic Immune Modulator in Oral Cancer?
por: Trumet, Leah, et al.
Publicado: (2023)

Expression of Msx-1 is suppressed in bisphosphonate associated osteonecrosis related jaw tissue-etiopathology considerations respecting jaw developmental biology-related unique features
por: Wehrhan, Falk, et al.
Publicado: (2010)

Osteonecrosis of the jaw in a Crohn’s disease patient following a course of Bisphosphonate and Adalimumab therapy: a case report
por: Preidl, Raimund HM, et al.
Publicado: (2014)

Macrophage polarisation changes within the time between diagnostic biopsy and tumour resection in oral squamous cell carcinomas—an immunohistochemical study
por: Weber, M, et al.
Publicado: (2015)

Macrophage and T-Cell Infiltration and Topographic Immune Cell Distribution in Non-Melanoma Skin Cancer of the Head and Neck
por: Frohwitter, Gesche, et al.
Publicado: (2022)

DICER1-Mutated Botryoid Fibroepithelial Polyp of the Parotid Duct: Report of the First Case
por: Erber, Ramona, et al.
Publicado: (2021)

Beyond PD-L1—Identification of Further Potential Therapeutic Targets in Oral Cancer
por: Weber, Manuel, et al.
Publicado: (2022)

Pedicled buccal flaps as a backup procedure for intraoral reconstruction
por: Frohwitter, Gesche, et al.
Publicado: (2022)

Expression of inflammatory mediators in biofilm samples and clinical association in inflammatory bowel disease patients—a preliminary study
por: Buchbender, Mayte, et al.
Publicado: (2021)

Bisphosphonate-associated osteonecrosis of the jaw is linked to suppressed TGFβ1-signaling and increased Galectin-3 expression: A histological study on biopsies
por: Wehrhan, Falk, et al.
Publicado: (2011)

Zoledronic acid exacerbates inflammation through M1 macrophage polarization
por: Kaneko, Junya, et al.
Publicado: (2018)

Case report: Patient specific combination of surgery and immunotherapy in advanced squamous cell carcinoma of the head and neck – a case series and review of literature
por: Olmos, Manuel, et al.
Publicado: (2022)

Neoadjuvant Immunotherapy of Oral Squamous Cell Carcinoma: Case Report and Assessment of Histological Response
por: Olmos, Manuel, et al.
Publicado: (2021)

Investigation of the Expression of Inflammatory Markers in Oral Biofilm Samples in Patients with Systemic Scleroderma and the Association with Clinical Periodontal Parameters—A Preliminary Study
por: Buchbender, Mayte, et al.
Publicado: (2021)

Zoledronic acid impairs stromal reactivity by inhibiting M2-macrophages polarization and prostate cancer-associated fibroblasts
por: Comito, Giuseppina, et al.
Publicado: (2016)

Early MDO with a Virtually Planned Distractor in a Neonate with Pierre Robin Sequence
por: Lutz, Rainer, et al.
Publicado: (2022)

An ex vivo model for education and training of unilateral cleft lip surgery
por: Lutz, Rainer, et al.
Publicado: (2023)

Cryoablation combined with zoledronic acid in comparison with cryoablation and zoledronic acid alone in the treatment of painful bone metastases
por: LI, FENQIANG, et al.
Publicado: (2014)

Theory of polarization shifts in exotic atoms
por: Ericson, Torleif Eric Oskar, et al.
Publicado: (1972)

Case report: upper arm metastasis of an oral squamous cell carcinoma
por: Wurm, Matthias Christian, et al.
Publicado: (2015)

The effect of zoledronate during bone healing
por: Matos, Marcos Almeida, et al.
Publicado: (2010)

The anti-tumour effects of zoledronic acid
por: Zekri, Jamal, et al.
Publicado: (2014)

Zoledronic Acid–Induced Interface Dermatitis
por: Succaria, Farah, et al.
Publicado: (2015)

Estradiol impairs the antiproliferative and proapoptotic effect of Zoledronic acid in hormone sensitive breast cancer cells in vitro
por: Gschwantler-Kaulich, Daphne, et al.
Publicado: (2017)

Cost-Effectiveness of Sequential Teriparatide/Zoledronic Acid Compared With Zoledronic Acid Monotherapy for Postmenopausal Osteoporotic Women in China
por: You, Ruxu, et al.
Publicado: (2022)

Cost-Effectiveness of Sequential Denosumab/Zoledronic Acid Compared With Zoledronic Acid Monotherapy for Postmenopausal Osteoporotic Women in China
por: You, Ruxu, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_cc5lk9k4ai46trb3hjmcpnv8oi