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New Highlights of Resveratrol: A Review of Properties against Ocular Diseases

Eye diseases are currently a major public health concern due to the growing number of cases resulting from both an aging of populations and exogenous factors linked to our lifestyles. Thus, many treatments including surgical pharmacological approaches have emerged, and special attention has been pai...

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Autores principales: Delmas, Dominique, Cornebise, Clarisse, Courtaut, Flavie, Xiao, Jianbo, Aires, Virginie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865717/
https://www.ncbi.nlm.nih.gov/pubmed/33525499
http://dx.doi.org/10.3390/ijms22031295
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author Delmas, Dominique
Cornebise, Clarisse
Courtaut, Flavie
Xiao, Jianbo
Aires, Virginie
author_facet Delmas, Dominique
Cornebise, Clarisse
Courtaut, Flavie
Xiao, Jianbo
Aires, Virginie
author_sort Delmas, Dominique
collection PubMed
description Eye diseases are currently a major public health concern due to the growing number of cases resulting from both an aging of populations and exogenous factors linked to our lifestyles. Thus, many treatments including surgical pharmacological approaches have emerged, and special attention has been paid to prevention, where diet plays a preponderant role. Recently, potential antioxidants such as resveratrol have received much attention as potential tools against various ocular diseases. In this review, we focus on the mechanisms of resveratrol against ocular diseases, in particular age-related macular degeneration, glaucoma, cataract, diabetic retinopathy, and vitreoretinopathy. We analyze, in relation to the different steps of each disease, the resveratrol properties at multiple levels, such as cellular and molecular signaling as well as physiological effects. We show and discuss the relationship to reactive oxygen species, the regulation of inflammatory process, and how resveratrol can prevent ocular diseases through a potential epigenetic action by the activation of sirtuin-1. Lastly, various new forms of resveratrol delivery are emerging at the same time as some clinical trials are raising more questions about the future of resveratrol as a potential tool for prevention or in therapeutic strategies against ocular diseases. More preclinical studies are required to provide further insights into RSV’s potential adjuvant activity.
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spelling pubmed-78657172021-02-07 New Highlights of Resveratrol: A Review of Properties against Ocular Diseases Delmas, Dominique Cornebise, Clarisse Courtaut, Flavie Xiao, Jianbo Aires, Virginie Int J Mol Sci Review Eye diseases are currently a major public health concern due to the growing number of cases resulting from both an aging of populations and exogenous factors linked to our lifestyles. Thus, many treatments including surgical pharmacological approaches have emerged, and special attention has been paid to prevention, where diet plays a preponderant role. Recently, potential antioxidants such as resveratrol have received much attention as potential tools against various ocular diseases. In this review, we focus on the mechanisms of resveratrol against ocular diseases, in particular age-related macular degeneration, glaucoma, cataract, diabetic retinopathy, and vitreoretinopathy. We analyze, in relation to the different steps of each disease, the resveratrol properties at multiple levels, such as cellular and molecular signaling as well as physiological effects. We show and discuss the relationship to reactive oxygen species, the regulation of inflammatory process, and how resveratrol can prevent ocular diseases through a potential epigenetic action by the activation of sirtuin-1. Lastly, various new forms of resveratrol delivery are emerging at the same time as some clinical trials are raising more questions about the future of resveratrol as a potential tool for prevention or in therapeutic strategies against ocular diseases. More preclinical studies are required to provide further insights into RSV’s potential adjuvant activity. MDPI 2021-01-28 /pmc/articles/PMC7865717/ /pubmed/33525499 http://dx.doi.org/10.3390/ijms22031295 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Delmas, Dominique
Cornebise, Clarisse
Courtaut, Flavie
Xiao, Jianbo
Aires, Virginie
New Highlights of Resveratrol: A Review of Properties against Ocular Diseases
title New Highlights of Resveratrol: A Review of Properties against Ocular Diseases
title_full New Highlights of Resveratrol: A Review of Properties against Ocular Diseases
title_fullStr New Highlights of Resveratrol: A Review of Properties against Ocular Diseases
title_full_unstemmed New Highlights of Resveratrol: A Review of Properties against Ocular Diseases
title_short New Highlights of Resveratrol: A Review of Properties against Ocular Diseases
title_sort new highlights of resveratrol: a review of properties against ocular diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865717/
https://www.ncbi.nlm.nih.gov/pubmed/33525499
http://dx.doi.org/10.3390/ijms22031295
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