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Comprehensive Review on the Clinical Relevance of Long Non-Coding RNAs in Cutaneous Melanoma
Cutaneous melanoma is considered a rare tumor, although it is one of the most common cancers in young adults and its incidence has risen in the last decades. Targeted therapy, with BRAF and MEK inhibitors, and immunotherapy revolutionized the treatment of metastatic melanoma but there is still a con...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865742/ https://www.ncbi.nlm.nih.gov/pubmed/33503876 http://dx.doi.org/10.3390/ijms22031166 |
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author | De Falco, Vincenzo Napolitano, Stefania Esposito, Daniela Guerrera, Luigi Pio Ciardiello, Davide Formisano, Luigi Troiani, Teresa |
author_facet | De Falco, Vincenzo Napolitano, Stefania Esposito, Daniela Guerrera, Luigi Pio Ciardiello, Davide Formisano, Luigi Troiani, Teresa |
author_sort | De Falco, Vincenzo |
collection | PubMed |
description | Cutaneous melanoma is considered a rare tumor, although it is one of the most common cancers in young adults and its incidence has risen in the last decades. Targeted therapy, with BRAF and MEK inhibitors, and immunotherapy revolutionized the treatment of metastatic melanoma but there is still a considerable percentage of patients with primary or acquired resistance to these therapies. Recently, oncology researchers directed their attention at the role of long non-coding RNAs (lncRNAs) in different types of cancers, including melanoma. lncRNAs are RNA transcripts, initially considered “junk sequences”, that have been proven to have a crucial role in the fine regulation of physiological and pathological processes of different tissues. Furthermore, they are more expressed in tumors than protein-coding genes, constituting perfect candidates either as biomarkers (diagnostic, prognostic, predictive) or as therapeutic targets. In this work, we reviewed all the literature available for lncRNA in melanoma, elucidating all the potential roles in this tumor. |
format | Online Article Text |
id | pubmed-7865742 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-78657422021-02-07 Comprehensive Review on the Clinical Relevance of Long Non-Coding RNAs in Cutaneous Melanoma De Falco, Vincenzo Napolitano, Stefania Esposito, Daniela Guerrera, Luigi Pio Ciardiello, Davide Formisano, Luigi Troiani, Teresa Int J Mol Sci Review Cutaneous melanoma is considered a rare tumor, although it is one of the most common cancers in young adults and its incidence has risen in the last decades. Targeted therapy, with BRAF and MEK inhibitors, and immunotherapy revolutionized the treatment of metastatic melanoma but there is still a considerable percentage of patients with primary or acquired resistance to these therapies. Recently, oncology researchers directed their attention at the role of long non-coding RNAs (lncRNAs) in different types of cancers, including melanoma. lncRNAs are RNA transcripts, initially considered “junk sequences”, that have been proven to have a crucial role in the fine regulation of physiological and pathological processes of different tissues. Furthermore, they are more expressed in tumors than protein-coding genes, constituting perfect candidates either as biomarkers (diagnostic, prognostic, predictive) or as therapeutic targets. In this work, we reviewed all the literature available for lncRNA in melanoma, elucidating all the potential roles in this tumor. MDPI 2021-01-25 /pmc/articles/PMC7865742/ /pubmed/33503876 http://dx.doi.org/10.3390/ijms22031166 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review De Falco, Vincenzo Napolitano, Stefania Esposito, Daniela Guerrera, Luigi Pio Ciardiello, Davide Formisano, Luigi Troiani, Teresa Comprehensive Review on the Clinical Relevance of Long Non-Coding RNAs in Cutaneous Melanoma |
title | Comprehensive Review on the Clinical Relevance of Long Non-Coding RNAs in Cutaneous Melanoma |
title_full | Comprehensive Review on the Clinical Relevance of Long Non-Coding RNAs in Cutaneous Melanoma |
title_fullStr | Comprehensive Review on the Clinical Relevance of Long Non-Coding RNAs in Cutaneous Melanoma |
title_full_unstemmed | Comprehensive Review on the Clinical Relevance of Long Non-Coding RNAs in Cutaneous Melanoma |
title_short | Comprehensive Review on the Clinical Relevance of Long Non-Coding RNAs in Cutaneous Melanoma |
title_sort | comprehensive review on the clinical relevance of long non-coding rnas in cutaneous melanoma |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865742/ https://www.ncbi.nlm.nih.gov/pubmed/33503876 http://dx.doi.org/10.3390/ijms22031166 |
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