The Role of GSH in Intracellular Iron Trafficking

Evidence is reviewed for the role of glutathione in providing a ligand for the cytosolic iron pool. The possibility of histidine and carnosine forming ternary complexes with iron(II)glutathione is discussed and the physiological significance of these interactions considered. The role of carnosine in...

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Detalles Bibliográficos
Autores principales: Hider, Robert, Aviles, Mayra Vera, Chen, Yu-Lin, Latunde-Dada, Gladys Oluyemisi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865746/
https://www.ncbi.nlm.nih.gov/pubmed/33525417
http://dx.doi.org/10.3390/ijms22031278
Descripción
Sumario:Evidence is reviewed for the role of glutathione in providing a ligand for the cytosolic iron pool. The possibility of histidine and carnosine forming ternary complexes with iron(II)glutathione is discussed and the physiological significance of these interactions considered. The role of carnosine in muscle, brain, and kidney physiology is far from established and evidence is presented that the iron(II)-binding capability of carnosine relates to this role.

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