The Role of GSH in Intracellular Iron Trafficking

Evidence is reviewed for the role of glutathione in providing a ligand for the cytosolic iron pool. The possibility of histidine and carnosine forming ternary complexes with iron(II)glutathione is discussed and the physiological significance of these interactions considered. The role of carnosine in...

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Autores principales: Hider, Robert, Aviles, Mayra Vera, Chen, Yu-Lin, Latunde-Dada, Gladys Oluyemisi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865746/
https://www.ncbi.nlm.nih.gov/pubmed/33525417
http://dx.doi.org/10.3390/ijms22031278
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author Hider, Robert
Aviles, Mayra Vera
Chen, Yu-Lin
Latunde-Dada, Gladys Oluyemisi
author_facet Hider, Robert
Aviles, Mayra Vera
Chen, Yu-Lin
Latunde-Dada, Gladys Oluyemisi
author_sort Hider, Robert
collection PubMed
description Evidence is reviewed for the role of glutathione in providing a ligand for the cytosolic iron pool. The possibility of histidine and carnosine forming ternary complexes with iron(II)glutathione is discussed and the physiological significance of these interactions considered. The role of carnosine in muscle, brain, and kidney physiology is far from established and evidence is presented that the iron(II)-binding capability of carnosine relates to this role.
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spelling pubmed-78657462021-02-07 The Role of GSH in Intracellular Iron Trafficking Hider, Robert Aviles, Mayra Vera Chen, Yu-Lin Latunde-Dada, Gladys Oluyemisi Int J Mol Sci Review Evidence is reviewed for the role of glutathione in providing a ligand for the cytosolic iron pool. The possibility of histidine and carnosine forming ternary complexes with iron(II)glutathione is discussed and the physiological significance of these interactions considered. The role of carnosine in muscle, brain, and kidney physiology is far from established and evidence is presented that the iron(II)-binding capability of carnosine relates to this role. MDPI 2021-01-28 /pmc/articles/PMC7865746/ /pubmed/33525417 http://dx.doi.org/10.3390/ijms22031278 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hider, Robert
Aviles, Mayra Vera
Chen, Yu-Lin
Latunde-Dada, Gladys Oluyemisi
The Role of GSH in Intracellular Iron Trafficking
title The Role of GSH in Intracellular Iron Trafficking
title_full The Role of GSH in Intracellular Iron Trafficking
title_fullStr The Role of GSH in Intracellular Iron Trafficking
title_full_unstemmed The Role of GSH in Intracellular Iron Trafficking
title_short The Role of GSH in Intracellular Iron Trafficking
title_sort role of gsh in intracellular iron trafficking
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865746/
https://www.ncbi.nlm.nih.gov/pubmed/33525417
http://dx.doi.org/10.3390/ijms22031278
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