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The Protective Role of Sestrin2 in Atherosclerotic and Cardiac Diseases
Atherosclerotic disease, such as coronary artery disease (CAD), is known to be a chronic inflammatory disease, as well as an age-related disease. Excessive oxidative stress produced by reactive oxygen species (ROS) contributes to the pathogenesis of atherosclerosis. Sestrin2 is an anti-oxidant prote...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865804/ https://www.ncbi.nlm.nih.gov/pubmed/33530433 http://dx.doi.org/10.3390/ijms22031200 |
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author | Kishimoto, Yoshimi Kondo, Kazuo Momiyama, Yukihiko |
author_facet | Kishimoto, Yoshimi Kondo, Kazuo Momiyama, Yukihiko |
author_sort | Kishimoto, Yoshimi |
collection | PubMed |
description | Atherosclerotic disease, such as coronary artery disease (CAD), is known to be a chronic inflammatory disease, as well as an age-related disease. Excessive oxidative stress produced by reactive oxygen species (ROS) contributes to the pathogenesis of atherosclerosis. Sestrin2 is an anti-oxidant protein that is induced by various stresses such as hypoxia, DNA damage, and oxidative stress. Sestrin2 is also suggested to be associated with aging. Sestrin2 is expressed and secreted mainly by macrophages, endothelial cells, and cardiomyocytes. Sestrin2 plays an important role in suppressing the production and accumulation of ROS, thus protecting cells from oxidative damage. Since sestrin2 is reported to have anti-oxidant and anti-inflammatory properties, it may play a protective role against the progression of atherosclerosis and may be a potential therapeutic target for the amelioration of atherosclerosis. Regarding the association between blood sestrin2 levels and atherosclerotic disease, the blood sestrin2 levels in patients with CAD or carotid atherosclerosis were reported to be high. High blood sestrin2 levels in patients with such atherosclerotic disease may reflect a compensatory response to increased oxidative stress and may help protect against the progression of atherosclerosis. This review describes the protective role of sestrin2 against the progression of atherosclerotic and cardiac diseases. |
format | Online Article Text |
id | pubmed-7865804 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-78658042021-02-07 The Protective Role of Sestrin2 in Atherosclerotic and Cardiac Diseases Kishimoto, Yoshimi Kondo, Kazuo Momiyama, Yukihiko Int J Mol Sci Review Atherosclerotic disease, such as coronary artery disease (CAD), is known to be a chronic inflammatory disease, as well as an age-related disease. Excessive oxidative stress produced by reactive oxygen species (ROS) contributes to the pathogenesis of atherosclerosis. Sestrin2 is an anti-oxidant protein that is induced by various stresses such as hypoxia, DNA damage, and oxidative stress. Sestrin2 is also suggested to be associated with aging. Sestrin2 is expressed and secreted mainly by macrophages, endothelial cells, and cardiomyocytes. Sestrin2 plays an important role in suppressing the production and accumulation of ROS, thus protecting cells from oxidative damage. Since sestrin2 is reported to have anti-oxidant and anti-inflammatory properties, it may play a protective role against the progression of atherosclerosis and may be a potential therapeutic target for the amelioration of atherosclerosis. Regarding the association between blood sestrin2 levels and atherosclerotic disease, the blood sestrin2 levels in patients with CAD or carotid atherosclerosis were reported to be high. High blood sestrin2 levels in patients with such atherosclerotic disease may reflect a compensatory response to increased oxidative stress and may help protect against the progression of atherosclerosis. This review describes the protective role of sestrin2 against the progression of atherosclerotic and cardiac diseases. MDPI 2021-01-26 /pmc/articles/PMC7865804/ /pubmed/33530433 http://dx.doi.org/10.3390/ijms22031200 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kishimoto, Yoshimi Kondo, Kazuo Momiyama, Yukihiko The Protective Role of Sestrin2 in Atherosclerotic and Cardiac Diseases |
title | The Protective Role of Sestrin2 in Atherosclerotic and Cardiac Diseases |
title_full | The Protective Role of Sestrin2 in Atherosclerotic and Cardiac Diseases |
title_fullStr | The Protective Role of Sestrin2 in Atherosclerotic and Cardiac Diseases |
title_full_unstemmed | The Protective Role of Sestrin2 in Atherosclerotic and Cardiac Diseases |
title_short | The Protective Role of Sestrin2 in Atherosclerotic and Cardiac Diseases |
title_sort | protective role of sestrin2 in atherosclerotic and cardiac diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865804/ https://www.ncbi.nlm.nih.gov/pubmed/33530433 http://dx.doi.org/10.3390/ijms22031200 |
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