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Profilin 1 and Mitochondria—Partners in the Pathogenesis of Coronary Artery Disease?

Atherosclerosis remains a large health and economic burden. Even though it has been studied for more than a century, its complex pathophysiology has not been elucidated. The relatively well-established contributors include: chronic inflammation in response to oxidized cholesterol, reactive oxygen sp...

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Autores principales: Paszek, Elżbieta, Zajdel, Wojciech, Rajs, Tomasz, Żmudka, Krzysztof, Legutko, Jacek, Kleczyński, Paweł
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865810/
https://www.ncbi.nlm.nih.gov/pubmed/33499277
http://dx.doi.org/10.3390/ijms22031100
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author Paszek, Elżbieta
Zajdel, Wojciech
Rajs, Tomasz
Żmudka, Krzysztof
Legutko, Jacek
Kleczyński, Paweł
author_facet Paszek, Elżbieta
Zajdel, Wojciech
Rajs, Tomasz
Żmudka, Krzysztof
Legutko, Jacek
Kleczyński, Paweł
author_sort Paszek, Elżbieta
collection PubMed
description Atherosclerosis remains a large health and economic burden. Even though it has been studied for more than a century, its complex pathophysiology has not been elucidated. The relatively well-established contributors include: chronic inflammation in response to oxidized cholesterol, reactive oxygen species-induced damage and apoptosis. Recently, profilin 1, a regulator of actin dynamics emerged as a potential new player in the field. Profilin is abundant in stable atherosclerotic plaques and in thrombi extracted from infarct-related arteries in patients with acute myocardial infarction. The exact role of profilin in atherosclerosis and its complications, as well as its mechanisms of action, remain unknown. Here, we summarize several pathways in which profilin may act through mitochondria in a number of processes implicated in atherosclerosis.
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spelling pubmed-78658102021-02-07 Profilin 1 and Mitochondria—Partners in the Pathogenesis of Coronary Artery Disease? Paszek, Elżbieta Zajdel, Wojciech Rajs, Tomasz Żmudka, Krzysztof Legutko, Jacek Kleczyński, Paweł Int J Mol Sci Review Atherosclerosis remains a large health and economic burden. Even though it has been studied for more than a century, its complex pathophysiology has not been elucidated. The relatively well-established contributors include: chronic inflammation in response to oxidized cholesterol, reactive oxygen species-induced damage and apoptosis. Recently, profilin 1, a regulator of actin dynamics emerged as a potential new player in the field. Profilin is abundant in stable atherosclerotic plaques and in thrombi extracted from infarct-related arteries in patients with acute myocardial infarction. The exact role of profilin in atherosclerosis and its complications, as well as its mechanisms of action, remain unknown. Here, we summarize several pathways in which profilin may act through mitochondria in a number of processes implicated in atherosclerosis. MDPI 2021-01-22 /pmc/articles/PMC7865810/ /pubmed/33499277 http://dx.doi.org/10.3390/ijms22031100 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Paszek, Elżbieta
Zajdel, Wojciech
Rajs, Tomasz
Żmudka, Krzysztof
Legutko, Jacek
Kleczyński, Paweł
Profilin 1 and Mitochondria—Partners in the Pathogenesis of Coronary Artery Disease?
title Profilin 1 and Mitochondria—Partners in the Pathogenesis of Coronary Artery Disease?
title_full Profilin 1 and Mitochondria—Partners in the Pathogenesis of Coronary Artery Disease?
title_fullStr Profilin 1 and Mitochondria—Partners in the Pathogenesis of Coronary Artery Disease?
title_full_unstemmed Profilin 1 and Mitochondria—Partners in the Pathogenesis of Coronary Artery Disease?
title_short Profilin 1 and Mitochondria—Partners in the Pathogenesis of Coronary Artery Disease?
title_sort profilin 1 and mitochondria—partners in the pathogenesis of coronary artery disease?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865810/
https://www.ncbi.nlm.nih.gov/pubmed/33499277
http://dx.doi.org/10.3390/ijms22031100
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