Effect of DNA Glycosylases OGG1 and Neil1 on Oxidized G-Rich Motif in the KRAS Promoter

The promoter of the Kirsten ras (KRAS) proto-oncogene contains, upstream of the transcription start site, a quadruplex-forming motif called 32R with regulatory functions. As guanine under oxidative stress can be oxidized to 8-oxoguanine (8OG), we investigated the capacity of glycosylases 8-oxoguanin...

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Detalles Bibliográficos
Autores principales: Ferino, Annalisa, Xodo, Luigi E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865940/
https://www.ncbi.nlm.nih.gov/pubmed/33498912
http://dx.doi.org/10.3390/ijms22031137

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865940/
https://www.ncbi.nlm.nih.gov/pubmed/33498912
http://dx.doi.org/10.3390/ijms22031137

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