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A Compact Multi-Distance DCS and Time Domain NIRS Hybrid System for Hemodynamic and Metabolic Measurements

In this work, we present a new multi-distance diffuse correlation spectroscopy (DCS) device integrated with a compact state-of-the-art time domain near infrared spectroscopy (TD-NIRS) device. The hybrid DCS and TD-NIRS system allows to retrieve information on blood flow, tissue oxygenation, and oxyg...

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Autores principales: Amendola, Caterina, Lacerenza, Michele, Buttafava, Mauro, Tosi, Alberto, Spinelli, Lorenzo, Contini, Davide, Torricelli, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866011/
https://www.ncbi.nlm.nih.gov/pubmed/33525488
http://dx.doi.org/10.3390/s21030870
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author Amendola, Caterina
Lacerenza, Michele
Buttafava, Mauro
Tosi, Alberto
Spinelli, Lorenzo
Contini, Davide
Torricelli, Alessandro
author_facet Amendola, Caterina
Lacerenza, Michele
Buttafava, Mauro
Tosi, Alberto
Spinelli, Lorenzo
Contini, Davide
Torricelli, Alessandro
author_sort Amendola, Caterina
collection PubMed
description In this work, we present a new multi-distance diffuse correlation spectroscopy (DCS) device integrated with a compact state-of-the-art time domain near infrared spectroscopy (TD-NIRS) device. The hybrid DCS and TD-NIRS system allows to retrieve information on blood flow, tissue oxygenation, and oxygen metabolic rate. The DCS device performances were estimated in terms of stability, repeatability, ability in retrieving variations of diffusion coefficient, influence of the tissue optical properties, effect of varying count rates and depth sensitivity. Crosstalk between DCS and TD-NIRS optical signals was also evaluated. Finally, in vivo experiments (venous and arterial cuff occlusions on the arm) were conducted to test the ability of the hybrid system in measuring blood flow variations.
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spelling pubmed-78660112021-02-07 A Compact Multi-Distance DCS and Time Domain NIRS Hybrid System for Hemodynamic and Metabolic Measurements Amendola, Caterina Lacerenza, Michele Buttafava, Mauro Tosi, Alberto Spinelli, Lorenzo Contini, Davide Torricelli, Alessandro Sensors (Basel) Article In this work, we present a new multi-distance diffuse correlation spectroscopy (DCS) device integrated with a compact state-of-the-art time domain near infrared spectroscopy (TD-NIRS) device. The hybrid DCS and TD-NIRS system allows to retrieve information on blood flow, tissue oxygenation, and oxygen metabolic rate. The DCS device performances were estimated in terms of stability, repeatability, ability in retrieving variations of diffusion coefficient, influence of the tissue optical properties, effect of varying count rates and depth sensitivity. Crosstalk between DCS and TD-NIRS optical signals was also evaluated. Finally, in vivo experiments (venous and arterial cuff occlusions on the arm) were conducted to test the ability of the hybrid system in measuring blood flow variations. MDPI 2021-01-28 /pmc/articles/PMC7866011/ /pubmed/33525488 http://dx.doi.org/10.3390/s21030870 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Amendola, Caterina
Lacerenza, Michele
Buttafava, Mauro
Tosi, Alberto
Spinelli, Lorenzo
Contini, Davide
Torricelli, Alessandro
A Compact Multi-Distance DCS and Time Domain NIRS Hybrid System for Hemodynamic and Metabolic Measurements
title A Compact Multi-Distance DCS and Time Domain NIRS Hybrid System for Hemodynamic and Metabolic Measurements
title_full A Compact Multi-Distance DCS and Time Domain NIRS Hybrid System for Hemodynamic and Metabolic Measurements
title_fullStr A Compact Multi-Distance DCS and Time Domain NIRS Hybrid System for Hemodynamic and Metabolic Measurements
title_full_unstemmed A Compact Multi-Distance DCS and Time Domain NIRS Hybrid System for Hemodynamic and Metabolic Measurements
title_short A Compact Multi-Distance DCS and Time Domain NIRS Hybrid System for Hemodynamic and Metabolic Measurements
title_sort compact multi-distance dcs and time domain nirs hybrid system for hemodynamic and metabolic measurements
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866011/
https://www.ncbi.nlm.nih.gov/pubmed/33525488
http://dx.doi.org/10.3390/s21030870
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