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DAXX Is a Crucial Factor for Proper Development of Mammalian Oocytes and Early Embryos

The Death-domain associated protein 6 (DAXX) is an evolutionarily conserved and ubiquitously expressed multifunctional protein that is implicated in many cellular processes, including transcription, cellular proliferation, cell cycle regulation, Fas-induced apoptosis, and many other events. In the n...

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Autores principales: Bogolyubova, Irina, Bogolyubov, Dmitry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866053/
https://www.ncbi.nlm.nih.gov/pubmed/33525665
http://dx.doi.org/10.3390/ijms22031313
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author Bogolyubova, Irina
Bogolyubov, Dmitry
author_facet Bogolyubova, Irina
Bogolyubov, Dmitry
author_sort Bogolyubova, Irina
collection PubMed
description The Death-domain associated protein 6 (DAXX) is an evolutionarily conserved and ubiquitously expressed multifunctional protein that is implicated in many cellular processes, including transcription, cellular proliferation, cell cycle regulation, Fas-induced apoptosis, and many other events. In the nucleus, DAXX interacts with transcription factors, epigenetic modifiers, and chromatin-remodeling proteins such as the transcription regulator ATRX—the α-thalassemia/mental retardation syndrome X-linked ATP-dependent helicase II. Accordingly, DAXX is considered one of the main players involved in chromatin silencing and one of the most important factors that maintain integrity of the genome. In this brief review, we summarize available data regarding the general and specific functions of DAXX in mammalian early development, with special emphasis on the function of DAXX as a chaperone of the histone variant H3.3. Since H3.3 plays a key role in the developmental processes, especially in the pronounced rearrangements of heterochromatin compartment during oogenesis and embryogenesis, DAXX can be considered as an important factor supporting proper development. Specifically, loss of DAXX affects the recruitment of ATRX, transcription of tandem repeats and telomere functions, which results in a decrease in the viability of early embryos.
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spelling pubmed-78660532021-02-07 DAXX Is a Crucial Factor for Proper Development of Mammalian Oocytes and Early Embryos Bogolyubova, Irina Bogolyubov, Dmitry Int J Mol Sci Review The Death-domain associated protein 6 (DAXX) is an evolutionarily conserved and ubiquitously expressed multifunctional protein that is implicated in many cellular processes, including transcription, cellular proliferation, cell cycle regulation, Fas-induced apoptosis, and many other events. In the nucleus, DAXX interacts with transcription factors, epigenetic modifiers, and chromatin-remodeling proteins such as the transcription regulator ATRX—the α-thalassemia/mental retardation syndrome X-linked ATP-dependent helicase II. Accordingly, DAXX is considered one of the main players involved in chromatin silencing and one of the most important factors that maintain integrity of the genome. In this brief review, we summarize available data regarding the general and specific functions of DAXX in mammalian early development, with special emphasis on the function of DAXX as a chaperone of the histone variant H3.3. Since H3.3 plays a key role in the developmental processes, especially in the pronounced rearrangements of heterochromatin compartment during oogenesis and embryogenesis, DAXX can be considered as an important factor supporting proper development. Specifically, loss of DAXX affects the recruitment of ATRX, transcription of tandem repeats and telomere functions, which results in a decrease in the viability of early embryos. MDPI 2021-01-28 /pmc/articles/PMC7866053/ /pubmed/33525665 http://dx.doi.org/10.3390/ijms22031313 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bogolyubova, Irina
Bogolyubov, Dmitry
DAXX Is a Crucial Factor for Proper Development of Mammalian Oocytes and Early Embryos
title DAXX Is a Crucial Factor for Proper Development of Mammalian Oocytes and Early Embryos
title_full DAXX Is a Crucial Factor for Proper Development of Mammalian Oocytes and Early Embryos
title_fullStr DAXX Is a Crucial Factor for Proper Development of Mammalian Oocytes and Early Embryos
title_full_unstemmed DAXX Is a Crucial Factor for Proper Development of Mammalian Oocytes and Early Embryos
title_short DAXX Is a Crucial Factor for Proper Development of Mammalian Oocytes and Early Embryos
title_sort daxx is a crucial factor for proper development of mammalian oocytes and early embryos
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866053/
https://www.ncbi.nlm.nih.gov/pubmed/33525665
http://dx.doi.org/10.3390/ijms22031313
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