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Age-Related Macular Degeneration: Role of Oxidative Stress and Blood Vessels
Age-related macular degeneration (AMD) is a common irreversible ocular disease characterized by vision impairment among older people. Many risk factors are related to AMD and interact with each other in its pathogenesis. Notably, oxidative stress and choroidal vascular dysfunction were suggested to...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866075/ https://www.ncbi.nlm.nih.gov/pubmed/33525498 http://dx.doi.org/10.3390/ijms22031296 |
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author | Ruan, Yue Jiang, Subao Gericke, Adrian |
author_facet | Ruan, Yue Jiang, Subao Gericke, Adrian |
author_sort | Ruan, Yue |
collection | PubMed |
description | Age-related macular degeneration (AMD) is a common irreversible ocular disease characterized by vision impairment among older people. Many risk factors are related to AMD and interact with each other in its pathogenesis. Notably, oxidative stress and choroidal vascular dysfunction were suggested to be critically involved in AMD pathogenesis. In this review, we give an overview on the factors contributing to the pathophysiology of this multifactorial disease and discuss the role of reactive oxygen species and vascular function in more detail. Moreover, we give an overview on therapeutic strategies for patients suffering from AMD. |
format | Online Article Text |
id | pubmed-7866075 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-78660752021-02-07 Age-Related Macular Degeneration: Role of Oxidative Stress and Blood Vessels Ruan, Yue Jiang, Subao Gericke, Adrian Int J Mol Sci Review Age-related macular degeneration (AMD) is a common irreversible ocular disease characterized by vision impairment among older people. Many risk factors are related to AMD and interact with each other in its pathogenesis. Notably, oxidative stress and choroidal vascular dysfunction were suggested to be critically involved in AMD pathogenesis. In this review, we give an overview on the factors contributing to the pathophysiology of this multifactorial disease and discuss the role of reactive oxygen species and vascular function in more detail. Moreover, we give an overview on therapeutic strategies for patients suffering from AMD. MDPI 2021-01-28 /pmc/articles/PMC7866075/ /pubmed/33525498 http://dx.doi.org/10.3390/ijms22031296 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ruan, Yue Jiang, Subao Gericke, Adrian Age-Related Macular Degeneration: Role of Oxidative Stress and Blood Vessels |
title | Age-Related Macular Degeneration: Role of Oxidative Stress and Blood Vessels |
title_full | Age-Related Macular Degeneration: Role of Oxidative Stress and Blood Vessels |
title_fullStr | Age-Related Macular Degeneration: Role of Oxidative Stress and Blood Vessels |
title_full_unstemmed | Age-Related Macular Degeneration: Role of Oxidative Stress and Blood Vessels |
title_short | Age-Related Macular Degeneration: Role of Oxidative Stress and Blood Vessels |
title_sort | age-related macular degeneration: role of oxidative stress and blood vessels |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866075/ https://www.ncbi.nlm.nih.gov/pubmed/33525498 http://dx.doi.org/10.3390/ijms22031296 |
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