PEG Linker Length Strongly Affects Tumor Cell Killing by PEGylated Carbonic Anhydrase Inhibitors in Hypoxic Carcinomas Expressing Carbonic Anhydrase IX

Hypoxic tumors overexpress membrane-bound isozymes of carbonic anhydrase (CA) CA IX and CA XII, which play key roles in tumor pH homeostasis under hypoxia. Selective inhibition of these CA isozymes has the potential to generate pH imbalances that can lead to tumor cell death. Since these isozymes ar...

Descripción completa

Detalles Bibliográficos
Autores principales: Mondal, Utpal K., Doroba, Kate, Shabana, Ahmed M., Adelberg, Rachel, Alam, Md. Raqibul, Supuran, Claudiu T., Ilies, Marc A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866101/
https://www.ncbi.nlm.nih.gov/pubmed/33498779
http://dx.doi.org/10.3390/ijms22031120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866101/
https://www.ncbi.nlm.nih.gov/pubmed/33498779
http://dx.doi.org/10.3390/ijms22031120

Ejemplares similares