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Adiponectin as a Potential Biomarker for Pregnancy Disorders

Adiponectin is an adipocyte-derived hormone that plays a critical role in energy homeostasis, mainly attributed to its insulin-sensitizing properties. Accumulating studies have reported that adiponectin concentrations are decreased during metabolic diseases, such as obesity and type 2 diabetes, with...

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Autores principales: Pheiffer, Carmen, Dias, Stephanie, Jack, Babalwa, Malaza, Nompumelelo, Adam, Sumaiya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866110/
https://www.ncbi.nlm.nih.gov/pubmed/33572712
http://dx.doi.org/10.3390/ijms22031326
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author Pheiffer, Carmen
Dias, Stephanie
Jack, Babalwa
Malaza, Nompumelelo
Adam, Sumaiya
author_facet Pheiffer, Carmen
Dias, Stephanie
Jack, Babalwa
Malaza, Nompumelelo
Adam, Sumaiya
author_sort Pheiffer, Carmen
collection PubMed
description Adiponectin is an adipocyte-derived hormone that plays a critical role in energy homeostasis, mainly attributed to its insulin-sensitizing properties. Accumulating studies have reported that adiponectin concentrations are decreased during metabolic diseases, such as obesity and type 2 diabetes, with an emerging body of evidence providing support for its use as a biomarker for pregnancy complications. The identification of maternal factors that could predict the outcome of compromised pregnancies could act as valuable tools that allow the early recognition of high-risk pregnancies, facilitating close follow-up and prevention of pregnancy complications in mother and child. In this review we consider the role of adiponectin as a potential biomarker of disorders associated with pregnancy. We discuss common disorders associated with pregnancy (gestational diabetes mellitus, preeclampsia, preterm birth and abnormal intrauterine growth) and highlight studies that have investigated the potential of adiponectin to serve as biomarkers for these disorders. We conclude the review by recommending strategies to consider for future research.
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spelling pubmed-78661102021-02-07 Adiponectin as a Potential Biomarker for Pregnancy Disorders Pheiffer, Carmen Dias, Stephanie Jack, Babalwa Malaza, Nompumelelo Adam, Sumaiya Int J Mol Sci Review Adiponectin is an adipocyte-derived hormone that plays a critical role in energy homeostasis, mainly attributed to its insulin-sensitizing properties. Accumulating studies have reported that adiponectin concentrations are decreased during metabolic diseases, such as obesity and type 2 diabetes, with an emerging body of evidence providing support for its use as a biomarker for pregnancy complications. The identification of maternal factors that could predict the outcome of compromised pregnancies could act as valuable tools that allow the early recognition of high-risk pregnancies, facilitating close follow-up and prevention of pregnancy complications in mother and child. In this review we consider the role of adiponectin as a potential biomarker of disorders associated with pregnancy. We discuss common disorders associated with pregnancy (gestational diabetes mellitus, preeclampsia, preterm birth and abnormal intrauterine growth) and highlight studies that have investigated the potential of adiponectin to serve as biomarkers for these disorders. We conclude the review by recommending strategies to consider for future research. MDPI 2021-01-29 /pmc/articles/PMC7866110/ /pubmed/33572712 http://dx.doi.org/10.3390/ijms22031326 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pheiffer, Carmen
Dias, Stephanie
Jack, Babalwa
Malaza, Nompumelelo
Adam, Sumaiya
Adiponectin as a Potential Biomarker for Pregnancy Disorders
title Adiponectin as a Potential Biomarker for Pregnancy Disorders
title_full Adiponectin as a Potential Biomarker for Pregnancy Disorders
title_fullStr Adiponectin as a Potential Biomarker for Pregnancy Disorders
title_full_unstemmed Adiponectin as a Potential Biomarker for Pregnancy Disorders
title_short Adiponectin as a Potential Biomarker for Pregnancy Disorders
title_sort adiponectin as a potential biomarker for pregnancy disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866110/
https://www.ncbi.nlm.nih.gov/pubmed/33572712
http://dx.doi.org/10.3390/ijms22031326
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