Development of MTH1-Binding Nucleotide Analogs Based on 7,8-Dihalogenated 7-Deaza-dG Derivatives

MTH1 is an enzyme that hydrolyzes 8-oxo-dGTP, which is an oxidatively damaged nucleobase, into 8-oxo-dGMP in nucleotide pools to prevent its mis-incorporation into genomic DNA. Selective and potent MTH1-binding molecules have potential as biological tools and drug candidates. We recently developed 8...

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Detalles Bibliográficos
Autores principales: Shi, Hui, Ishikawa, Ren, Heh, Choon Han, Sasaki, Shigeki, Taniguchi, Yosuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866122/
https://www.ncbi.nlm.nih.gov/pubmed/33525366
http://dx.doi.org/10.3390/ijms22031274

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866122/
https://www.ncbi.nlm.nih.gov/pubmed/33525366
http://dx.doi.org/10.3390/ijms22031274

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