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Multi-Organ Involvement in COVID-19: Beyond Pulmonary Manifestations
Coronavirus Disease 19 (COVID-19), due to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has become an on-going global health emergency affecting over 94 million cases with more than 2 million deaths globally. Primarily identified as atypical pneumonia, it has developed into severe acu...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866189/ https://www.ncbi.nlm.nih.gov/pubmed/33498861 http://dx.doi.org/10.3390/jcm10030446 |
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author | Thakur, Vikram Ratho, Radha Kanta Kumar, Pradeep Bhatia, Shashi Kant Bora, Ishani Mohi, Gursimran Kaur Saxena, Shailendra K Devi, Manju Yadav, Dhananjay Mehariya, Sanjeet |
author_facet | Thakur, Vikram Ratho, Radha Kanta Kumar, Pradeep Bhatia, Shashi Kant Bora, Ishani Mohi, Gursimran Kaur Saxena, Shailendra K Devi, Manju Yadav, Dhananjay Mehariya, Sanjeet |
author_sort | Thakur, Vikram |
collection | PubMed |
description | Coronavirus Disease 19 (COVID-19), due to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has become an on-going global health emergency affecting over 94 million cases with more than 2 million deaths globally. Primarily identified as atypical pneumonia, it has developed into severe acute respiratory distress syndrome (ARDS), a multi-organ dysfunction with associated fatality. Ever since its emergence, COVID-19 with its plethora of clinical presentations has signalled its dynamic nature and versatility of the disease process. Being a disease with droplet transmission has now assumed the proportion of a suspected airborne nature which, once proved, poses a Herculean task to control. Because of the wide distribution of the human angiotensin-converting enzyme-2 (hACE2) receptors, known for its transmission, we envisage its multiorgan spread and extensive disease distribution. Thus, an extensive review of the extrapulmonary organotropism of SARS-CoV-2 with organ-specific pathophysiology and associated manifestations like dermatological complications, myocardial dysfunction, gastrointestinal symptoms, neurologic illnesses, hepatic and renal injury is needed urgently. The plausible mechanism of site-specific viral invasion is also discussed to give a comprehensive understanding of disease complexity, to help us to focus on research priorities and therapeutic strategies to counter the disease progression. A note on the latest advancements in vaccine research will enlighten the scientific world and equip it for better preparedness. |
format | Online Article Text |
id | pubmed-7866189 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-78661892021-02-07 Multi-Organ Involvement in COVID-19: Beyond Pulmonary Manifestations Thakur, Vikram Ratho, Radha Kanta Kumar, Pradeep Bhatia, Shashi Kant Bora, Ishani Mohi, Gursimran Kaur Saxena, Shailendra K Devi, Manju Yadav, Dhananjay Mehariya, Sanjeet J Clin Med Review Coronavirus Disease 19 (COVID-19), due to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has become an on-going global health emergency affecting over 94 million cases with more than 2 million deaths globally. Primarily identified as atypical pneumonia, it has developed into severe acute respiratory distress syndrome (ARDS), a multi-organ dysfunction with associated fatality. Ever since its emergence, COVID-19 with its plethora of clinical presentations has signalled its dynamic nature and versatility of the disease process. Being a disease with droplet transmission has now assumed the proportion of a suspected airborne nature which, once proved, poses a Herculean task to control. Because of the wide distribution of the human angiotensin-converting enzyme-2 (hACE2) receptors, known for its transmission, we envisage its multiorgan spread and extensive disease distribution. Thus, an extensive review of the extrapulmonary organotropism of SARS-CoV-2 with organ-specific pathophysiology and associated manifestations like dermatological complications, myocardial dysfunction, gastrointestinal symptoms, neurologic illnesses, hepatic and renal injury is needed urgently. The plausible mechanism of site-specific viral invasion is also discussed to give a comprehensive understanding of disease complexity, to help us to focus on research priorities and therapeutic strategies to counter the disease progression. A note on the latest advancements in vaccine research will enlighten the scientific world and equip it for better preparedness. MDPI 2021-01-24 /pmc/articles/PMC7866189/ /pubmed/33498861 http://dx.doi.org/10.3390/jcm10030446 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Thakur, Vikram Ratho, Radha Kanta Kumar, Pradeep Bhatia, Shashi Kant Bora, Ishani Mohi, Gursimran Kaur Saxena, Shailendra K Devi, Manju Yadav, Dhananjay Mehariya, Sanjeet Multi-Organ Involvement in COVID-19: Beyond Pulmonary Manifestations |
title | Multi-Organ Involvement in COVID-19: Beyond Pulmonary Manifestations |
title_full | Multi-Organ Involvement in COVID-19: Beyond Pulmonary Manifestations |
title_fullStr | Multi-Organ Involvement in COVID-19: Beyond Pulmonary Manifestations |
title_full_unstemmed | Multi-Organ Involvement in COVID-19: Beyond Pulmonary Manifestations |
title_short | Multi-Organ Involvement in COVID-19: Beyond Pulmonary Manifestations |
title_sort | multi-organ involvement in covid-19: beyond pulmonary manifestations |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866189/ https://www.ncbi.nlm.nih.gov/pubmed/33498861 http://dx.doi.org/10.3390/jcm10030446 |
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