Laccase-Catalyzed 1,4-Dioxane-Mediated Synthesis of Belladine N-Oxides with Anti-Influenza A Virus Activity

Belladine N-oxides active against influenza A virus have been synthetized by a novel laccase-catalyzed 1,4-dioxane-mediated oxidation of aromatic and side-chain modified belladine derivatives. Electron paramagnetic resonance (EPR) analysis confirmed the role of 1,4-dioxane as a co-oxidant. The react...

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Autores principales: Zippilli, Claudio, Botta, Lorenzo, Bizzarri, Bruno Mattia, Nencioni, Lucia, De Angelis, Marta, Protto, Virginia, Giorgi, Gianluca, Baratto, Maria Camilla, Pogni, Rebecca, Saladino, Raffaele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866262/
https://www.ncbi.nlm.nih.gov/pubmed/33572794
http://dx.doi.org/10.3390/ijms22031337
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author Zippilli, Claudio
Botta, Lorenzo
Bizzarri, Bruno Mattia
Nencioni, Lucia
De Angelis, Marta
Protto, Virginia
Giorgi, Gianluca
Baratto, Maria Camilla
Pogni, Rebecca
Saladino, Raffaele
author_facet Zippilli, Claudio
Botta, Lorenzo
Bizzarri, Bruno Mattia
Nencioni, Lucia
De Angelis, Marta
Protto, Virginia
Giorgi, Gianluca
Baratto, Maria Camilla
Pogni, Rebecca
Saladino, Raffaele
author_sort Zippilli, Claudio
collection PubMed
description Belladine N-oxides active against influenza A virus have been synthetized by a novel laccase-catalyzed 1,4-dioxane-mediated oxidation of aromatic and side-chain modified belladine derivatives. Electron paramagnetic resonance (EPR) analysis confirmed the role of 1,4-dioxane as a co-oxidant. The reaction was chemo-selective, showing a high functional-group compatibility. The novel belladine N-oxides were active against influenza A virus, involving the early stage of the virus replication life cycle.
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spelling pubmed-78662622021-02-07 Laccase-Catalyzed 1,4-Dioxane-Mediated Synthesis of Belladine N-Oxides with Anti-Influenza A Virus Activity Zippilli, Claudio Botta, Lorenzo Bizzarri, Bruno Mattia Nencioni, Lucia De Angelis, Marta Protto, Virginia Giorgi, Gianluca Baratto, Maria Camilla Pogni, Rebecca Saladino, Raffaele Int J Mol Sci Article Belladine N-oxides active against influenza A virus have been synthetized by a novel laccase-catalyzed 1,4-dioxane-mediated oxidation of aromatic and side-chain modified belladine derivatives. Electron paramagnetic resonance (EPR) analysis confirmed the role of 1,4-dioxane as a co-oxidant. The reaction was chemo-selective, showing a high functional-group compatibility. The novel belladine N-oxides were active against influenza A virus, involving the early stage of the virus replication life cycle. MDPI 2021-01-29 /pmc/articles/PMC7866262/ /pubmed/33572794 http://dx.doi.org/10.3390/ijms22031337 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zippilli, Claudio
Botta, Lorenzo
Bizzarri, Bruno Mattia
Nencioni, Lucia
De Angelis, Marta
Protto, Virginia
Giorgi, Gianluca
Baratto, Maria Camilla
Pogni, Rebecca
Saladino, Raffaele
Laccase-Catalyzed 1,4-Dioxane-Mediated Synthesis of Belladine N-Oxides with Anti-Influenza A Virus Activity
title Laccase-Catalyzed 1,4-Dioxane-Mediated Synthesis of Belladine N-Oxides with Anti-Influenza A Virus Activity
title_full Laccase-Catalyzed 1,4-Dioxane-Mediated Synthesis of Belladine N-Oxides with Anti-Influenza A Virus Activity
title_fullStr Laccase-Catalyzed 1,4-Dioxane-Mediated Synthesis of Belladine N-Oxides with Anti-Influenza A Virus Activity
title_full_unstemmed Laccase-Catalyzed 1,4-Dioxane-Mediated Synthesis of Belladine N-Oxides with Anti-Influenza A Virus Activity
title_short Laccase-Catalyzed 1,4-Dioxane-Mediated Synthesis of Belladine N-Oxides with Anti-Influenza A Virus Activity
title_sort laccase-catalyzed 1,4-dioxane-mediated synthesis of belladine n-oxides with anti-influenza a virus activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866262/
https://www.ncbi.nlm.nih.gov/pubmed/33572794
http://dx.doi.org/10.3390/ijms22031337
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