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The Effect of TNF and Non-TNF-Targeted Biologics on Body Composition in Rheumatoid Arthritis

Rheumatoid arthritis (RA) is associated with a decrease in lean mass and stability or even an increase in fat and ectopic adipose tissue. A few data are available on body composition changes under treatment, and data are still controversial. Body composition was assessed before initiation of biologi...

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Autores principales: Vial, Gaelle, Lambert, Céline, Pereira, Bruno, Couderc, Marion, Malochet-Guinamand, Sandrine, Mathieu, Sylvain, Pickering, Marie Eva, Soubrier, Martin, Tournadre, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866419/
https://www.ncbi.nlm.nih.gov/pubmed/33573047
http://dx.doi.org/10.3390/jcm10030487
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author Vial, Gaelle
Lambert, Céline
Pereira, Bruno
Couderc, Marion
Malochet-Guinamand, Sandrine
Mathieu, Sylvain
Pickering, Marie Eva
Soubrier, Martin
Tournadre, Anne
author_facet Vial, Gaelle
Lambert, Céline
Pereira, Bruno
Couderc, Marion
Malochet-Guinamand, Sandrine
Mathieu, Sylvain
Pickering, Marie Eva
Soubrier, Martin
Tournadre, Anne
author_sort Vial, Gaelle
collection PubMed
description Rheumatoid arthritis (RA) is associated with a decrease in lean mass and stability or even an increase in fat and ectopic adipose tissue. A few data are available on body composition changes under treatment, and data are still controversial. Body composition was assessed before initiation of biologic disease-modifying antirheumatic drug (bDMARD) and after 6 and 12 months of stable treatment. Eighty-three RA patients were included (75% of women, mean age 58.5 ± 10.8 years) of whom 47 patients treated with TNF inhibitor (TNFi), 18 with non-TNF-targeted biologic (Non-TNFi), and 18 with conventional DMARD (cDMARD) alone. In the TNFi group, total lean mass, fat-free mass index, and skeletal muscle mass index significantly increased at 1 year. An increase in subcutaneous adipose tissue (SAT) without change for the visceral or body fat composition was associated. These changes were associated with an improvement in strength and walking test. In non-TNFi or cDMARD groups, no significant changes for body composition or muscle function were observed at 1 year. However, no significant differences for treatment x time interaction were noted between group treatments. In active RA patients starting first bDMARD, treatment with TNFi over 1 year was associated with favorable changes of the body composition and muscle function.
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spelling pubmed-78664192021-02-07 The Effect of TNF and Non-TNF-Targeted Biologics on Body Composition in Rheumatoid Arthritis Vial, Gaelle Lambert, Céline Pereira, Bruno Couderc, Marion Malochet-Guinamand, Sandrine Mathieu, Sylvain Pickering, Marie Eva Soubrier, Martin Tournadre, Anne J Clin Med Article Rheumatoid arthritis (RA) is associated with a decrease in lean mass and stability or even an increase in fat and ectopic adipose tissue. A few data are available on body composition changes under treatment, and data are still controversial. Body composition was assessed before initiation of biologic disease-modifying antirheumatic drug (bDMARD) and after 6 and 12 months of stable treatment. Eighty-three RA patients were included (75% of women, mean age 58.5 ± 10.8 years) of whom 47 patients treated with TNF inhibitor (TNFi), 18 with non-TNF-targeted biologic (Non-TNFi), and 18 with conventional DMARD (cDMARD) alone. In the TNFi group, total lean mass, fat-free mass index, and skeletal muscle mass index significantly increased at 1 year. An increase in subcutaneous adipose tissue (SAT) without change for the visceral or body fat composition was associated. These changes were associated with an improvement in strength and walking test. In non-TNFi or cDMARD groups, no significant changes for body composition or muscle function were observed at 1 year. However, no significant differences for treatment x time interaction were noted between group treatments. In active RA patients starting first bDMARD, treatment with TNFi over 1 year was associated with favorable changes of the body composition and muscle function. MDPI 2021-01-29 /pmc/articles/PMC7866419/ /pubmed/33573047 http://dx.doi.org/10.3390/jcm10030487 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Vial, Gaelle
Lambert, Céline
Pereira, Bruno
Couderc, Marion
Malochet-Guinamand, Sandrine
Mathieu, Sylvain
Pickering, Marie Eva
Soubrier, Martin
Tournadre, Anne
The Effect of TNF and Non-TNF-Targeted Biologics on Body Composition in Rheumatoid Arthritis
title The Effect of TNF and Non-TNF-Targeted Biologics on Body Composition in Rheumatoid Arthritis
title_full The Effect of TNF and Non-TNF-Targeted Biologics on Body Composition in Rheumatoid Arthritis
title_fullStr The Effect of TNF and Non-TNF-Targeted Biologics on Body Composition in Rheumatoid Arthritis
title_full_unstemmed The Effect of TNF and Non-TNF-Targeted Biologics on Body Composition in Rheumatoid Arthritis
title_short The Effect of TNF and Non-TNF-Targeted Biologics on Body Composition in Rheumatoid Arthritis
title_sort effect of tnf and non-tnf-targeted biologics on body composition in rheumatoid arthritis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866419/
https://www.ncbi.nlm.nih.gov/pubmed/33573047
http://dx.doi.org/10.3390/jcm10030487
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