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Melt-Spun Poly(D,L-lactic acid) Monofilaments Containing N,N-Diethyl-3-methylbenzamide as Mosquito Repellent

Malaria is still a major tropical disease, with Africa particularly burdened. It has been proposed that outdoor protection could aid substantially in reducing the malaria incidence rate in rural African communities. Recently, melt-spun polyolefin fibers containing mosquito repellents have been shown...

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Autores principales: Ferreira, Ignatius, Brünig, Harald, Focke, Walter, Boldt, Regine, Androsch, René, Leuteritz, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866511/
https://www.ncbi.nlm.nih.gov/pubmed/33573227
http://dx.doi.org/10.3390/ma14030638
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author Ferreira, Ignatius
Brünig, Harald
Focke, Walter
Boldt, Regine
Androsch, René
Leuteritz, Andreas
author_facet Ferreira, Ignatius
Brünig, Harald
Focke, Walter
Boldt, Regine
Androsch, René
Leuteritz, Andreas
author_sort Ferreira, Ignatius
collection PubMed
description Malaria is still a major tropical disease, with Africa particularly burdened. It has been proposed that outdoor protection could aid substantially in reducing the malaria incidence rate in rural African communities. Recently, melt-spun polyolefin fibers containing mosquito repellents have been shown to be promising materials to this end. In this study, the incorporation of N,N‑Diethyl‑3‑methylbenzamide (DEET)—a popular and widely available mosquito repellent—in commercially available, amorphous poly(D,L-lactic acid) (PDLLA) is investigated with the aim of producing biodegradable mosquito-repelling filaments with a reduced environmental impact. It is shown to be possible to produce macroscopically stable PDLLA-DEET compounds containing up to 20 wt.-% DEET that can be melt-spun to produce filaments, albeit at relatively low take-up speeds. A critical DEET content allows for stress-induced crystallization during the spinning of the otherwise amorphous PDLLA, resulting in the formation of α-crystals. Although the mechanical integrity of the filaments is notably impacted by the incorporation of DEET, these filaments show potential as materials that can be used for Malaria vector control.
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spelling pubmed-78665112021-02-07 Melt-Spun Poly(D,L-lactic acid) Monofilaments Containing N,N-Diethyl-3-methylbenzamide as Mosquito Repellent Ferreira, Ignatius Brünig, Harald Focke, Walter Boldt, Regine Androsch, René Leuteritz, Andreas Materials (Basel) Article Malaria is still a major tropical disease, with Africa particularly burdened. It has been proposed that outdoor protection could aid substantially in reducing the malaria incidence rate in rural African communities. Recently, melt-spun polyolefin fibers containing mosquito repellents have been shown to be promising materials to this end. In this study, the incorporation of N,N‑Diethyl‑3‑methylbenzamide (DEET)—a popular and widely available mosquito repellent—in commercially available, amorphous poly(D,L-lactic acid) (PDLLA) is investigated with the aim of producing biodegradable mosquito-repelling filaments with a reduced environmental impact. It is shown to be possible to produce macroscopically stable PDLLA-DEET compounds containing up to 20 wt.-% DEET that can be melt-spun to produce filaments, albeit at relatively low take-up speeds. A critical DEET content allows for stress-induced crystallization during the spinning of the otherwise amorphous PDLLA, resulting in the formation of α-crystals. Although the mechanical integrity of the filaments is notably impacted by the incorporation of DEET, these filaments show potential as materials that can be used for Malaria vector control. MDPI 2021-01-30 /pmc/articles/PMC7866511/ /pubmed/33573227 http://dx.doi.org/10.3390/ma14030638 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ferreira, Ignatius
Brünig, Harald
Focke, Walter
Boldt, Regine
Androsch, René
Leuteritz, Andreas
Melt-Spun Poly(D,L-lactic acid) Monofilaments Containing N,N-Diethyl-3-methylbenzamide as Mosquito Repellent
title Melt-Spun Poly(D,L-lactic acid) Monofilaments Containing N,N-Diethyl-3-methylbenzamide as Mosquito Repellent
title_full Melt-Spun Poly(D,L-lactic acid) Monofilaments Containing N,N-Diethyl-3-methylbenzamide as Mosquito Repellent
title_fullStr Melt-Spun Poly(D,L-lactic acid) Monofilaments Containing N,N-Diethyl-3-methylbenzamide as Mosquito Repellent
title_full_unstemmed Melt-Spun Poly(D,L-lactic acid) Monofilaments Containing N,N-Diethyl-3-methylbenzamide as Mosquito Repellent
title_short Melt-Spun Poly(D,L-lactic acid) Monofilaments Containing N,N-Diethyl-3-methylbenzamide as Mosquito Repellent
title_sort melt-spun poly(d,l-lactic acid) monofilaments containing n,n-diethyl-3-methylbenzamide as mosquito repellent
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866511/
https://www.ncbi.nlm.nih.gov/pubmed/33573227
http://dx.doi.org/10.3390/ma14030638
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