Cargando…

In Silico Study of Polyunsaturated Fatty Acids as Potential SARS-CoV-2 Spike Protein Closed Conformation Stabilizers: Epidemiological and Computational Approaches

SARS-CoV-2 infects host cells by interacting its spike protein with surface angiotensin-converting enzyme 2 (ACE2) receptors, expressed in lung and other cell types. Although several risk factors could explain why some countries have lower incidence and fatality rates than others, environmental fact...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vivar-Sierra, Alonso, Araiza-Macías, María José, Hernández-Contreras, José Patricio, Vergara-Castañeda, Arely, Ramírez-Vélez, Gabriela, Pinto-Almazán, Rodolfo, Salazar, Juan Rodrigo, Loza-Mejía, Marco A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866518/ https://www.ncbi.nlm.nih.gov/pubmed/33573088 http://dx.doi.org/10.3390/molecules26030711

Ejemplares similares

Chemistry, Biological Activities and In Silico Bioprospection of Sterols and Triterpenes from Mexican Columnar Cactaceae
por: Salazar, Juan Rodrigo, et al.
Publicado: (2020)

In Silico-Based Design and In Vivo Evaluation of an Anthranilic Acid Derivative as a Multitarget Drug in a Diet-Induced Metabolic Syndrome Model
por: González-Álvarez, Héctor, et al.
Publicado: (2021)

In Silico Studies on Compounds Derived from Calceolaria: Phenylethanoid Glycosides as Potential Multitarget Inhibitors for the Development of Pesticides
por: Loza-Mejía, Marco A., et al.
Publicado: (2018)

Structure-guided covalent stabilization of coronavirus spike glycoprotein trimers in the closed conformation
por: McCallum, Matthew, et al.
Publicado: (2020)

Spike protein of SARS-CoV-2 Omicron variant: An in-silico study evaluating spike interactions and immune evasion
por: Jimenez Ruiz, Jose A., et al.
Publicado: (2022)

High Fructose and High Fat Diet Impair Different Types of Memory through Oxidative Stress in a Sex- and Hormone-Dependent Manner
por: Chávez-Gutiérrez, Edwin, et al.
Publicado: (2022)

Maternal omega-3 polyunsaturated fatty acid supplementation on offspring hip joint conformation
por: Oberbauer, A. M., et al.
Publicado: (2018)

Effects of Tibolone on the Central Nervous System: Clinical and Experimental Approaches
por: Pinto-Almazán, Rodolfo, et al.
Publicado: (2017)

In Silico Exploration of Alternative Conformational States of VDAC
por: Mannella, Carmen
Publicado: (2023)

In Silico Evaluation of Sesquiterpenes and Benzoxazinoids Phytotoxins against M(pro), RNA Replicase and Spike Protein of SARS-CoV-2 by Molecular Dynamics. Inspired by Nature
por: Mejías, Francisco J. R., et al.
Publicado: (2022)

New Insights into Rotavirus Entry Machinery: Stabilization of Rotavirus Spike Conformation Is Independent of Trypsin Cleavage
por: Rodríguez, Javier M., et al.
Publicado: (2014)

Polyunsaturated Fatty Acids Modify the Gating of Kv Channels
por: Moreno, Cristina, et al.
Publicado: (2012)

In Combo Studies for the Optimization of 5-Aminoanthranilic Acid Derivatives as Potential Multitarget Drugs for the Management of Metabolic Syndrome
por: Chávez-Gutiérrez, Edwin, et al.
Publicado: (2022)

Natural effectors for conformational control of coronavirus spike proteins
por: Asarnow, Daniel, et al.
Publicado: (2023)

Effects of Spike Anticipation on the Spiking Dynamics of Neural Networks
por: de Santos-Sierra, Daniel, et al.
Publicado: (2015)

Analysis of the Neutralizing Activity of Antibodies Targeting Open or Closed SARS-CoV-2 Spike Protein Conformations
por: Cia, Gabriel, et al.
Publicado: (2022)

Effects of estrogen receptor modulators on cytoskeletal proteins in the central nervous system
por: Segura-Uribe, Julia J., et al.
Publicado: (2017)

Controlling the SARS-CoV-2 Spike Glycoprotein Conformation
por: Henderson, Rory, et al.
Publicado: (2020)

Controlling the SARS-CoV-2 spike glycoprotein conformation
por: Henderson, Rory, et al.
Publicado: (2020)

Coronavirus Pathogenicity is Determined by Stability of the Spike Protein Open Conformation
por: Bones, Josiah, et al.
Publicado: (2021)

Effects of local structure of neuronal networks on spiking activity in silico
por: Mäki-Marttunen, Tuomo, et al.
Publicado: (2011)

In Silico Investigation of Conformational Motions in Superfamily 2 Helicase Proteins
por: Flechsig, Holger, et al.
Publicado: (2011)

In Silico Conformational Analysis of the Short-Sequence Hypomurocin A Peptides
por: Násztor, Zoltán, et al.
Publicado: (2015)

Conformation of the Intermediates in the Reaction Catalyzed by Protoporphyrinogen Oxidase: An In Silico Analysis
por: Barker, Abigail L., et al.
Publicado: (2020)

Repositioning of Ligands That Target the Spike Glycoprotein as Potential Drugs for SARS-CoV-2 in an In Silico Study
por: Ramírez-Salinas, Gema Lizbeth, et al.
Publicado: (2020)

Effects of n−3 Polyunsaturated Fatty Acids on Cardiac Ion Channels
por: Moreno, Cristina, et al.
Publicado: (2012)

In-silico study for the identification of potential destabilizers between the spike protein of SARS-CoV-2 and human ACE-2
por: Medina-Barandica, Jeffry, et al.
Publicado: (2023)

Distinct conformational states of SARS-CoV-2 spike protein
por: Cai, Yongfei, et al.
Publicado: (2020)

Multiple conformations of trimeric spikes visualized on a non-enveloped virus
por: Zhang, Yinong, et al.
Publicado: (2022)

Essential Dynamics that Drive Sars-Cov-2 Spike Conformational Changes
por: Chakraborty, Srirupa, et al.
Publicado: (2021)

Conformational dynamics and allosteric modulation of the SARS-CoV-2 spike
por: Díaz-Salinas, Marco A, et al.
Publicado: (2022)

Conformational stability of SARS-CoV-2 glycoprotein spike variants
por: Arruda, Hiam R.S., et al.
Publicado: (2022)

Quantum Conformal Algebras and Closed Conformal Field Theory
por: Anselmi, D
Publicado: (1998)

TRP ion channels: Proteins with conformational flexibility
por: López-Romero, Ana Elena, et al.
Publicado: (2019)

Detecting parallel bursts in in silico generated parallel spike train data
por: Braune, Christian, et al.
Publicado: (2015)

Conformal mapping: methods and applications
por: Schinzinger, Roland, et al.
Publicado: (2003)

An in silico study of the molecular basis of B-RAF activation and conformational stability
por: Fratev, Filip F, et al.
Publicado: (2009)

Large-Scale Conformational Changes and Protein Function: Breaking the in silico Barrier
por: Orellana, Laura
Publicado: (2019)

In silico investigation of Alsin RLD conformational dynamics and phosphoinositides binding mechanism
por: Cannariato, Marco, et al.
Publicado: (2022)

FREQUENCY OF HEPATIC FUNCTION ALTERATION IN MEXICAN PATIENTS WITH COVID-19 AND ITS ASSOCIATION WITH THE SEVERITY OF ACUTE RESPIRATORY DISTRESS SYNDROME: PRELIMINARY RESULTS
por: Vera-Heredia, A.B., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_l72l0agt1eivgf8g069bicvi1l