Long non-coding RNA CIR inhibits chondrogenic differentiation of mesenchymal stem cells by epigenetically suppressing ATOH8 via methyltransferase EZH2

BACKGROUND: Osteoarthritis (OA) is the most common articular disorder, leading to joint malfunction and disability. Although the incidence of OA is increasing globally, the treatment of OA is very limited. LncRNA CIR has been implicated in OA through unclear mechanisms. Here, we investigated the rol...

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Detalles Bibliográficos
Autores principales: Liu, Feng, Song, De-Ye, Huang, Jun, Yang, Hong-Qi, You, Di, Ni, Jiang-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866678/
https://www.ncbi.nlm.nih.gov/pubmed/33546582
http://dx.doi.org/10.1186/s10020-021-00272-9

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