Cargando…

Role of Hypoxia-Mediated Autophagy in Tumor Cell Death and Survival

SIMPLE SUMMARY: Autophagy is a self-eating mechanism that is involved in the degradation of organelles and cellular materials. It is initiated by intracellular and extracellular stress stimuli. In the context of tumor development, microenvironmental hypoxic stress regulates autophagy that, in turn,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zaarour, Rania F., Azakir, Bilal, Hajam, Edries Y., Nawafleh, Husam, Zeinelabdin, Nagwa A., Engelsen, Agnete S.T., Thiery, Jérome, Jamora, Colin, Chouaib, Salem
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866864/ https://www.ncbi.nlm.nih.gov/pubmed/33573362 http://dx.doi.org/10.3390/cancers13030533

Ejemplares similares

The Effect of Hypoxia and Hypoxia-Associated Pathways in the Regulation of Antitumor Response: Friends or Foes?
por: Abou Khouzam, Raefa, et al.
Publicado: (2022)

Genomic Analysis of Waterpipe Smoke-Induced Lung Tumor Autophagy and Plasticity
por: Zaarour, Rania Faouzi, et al.
Publicado: (2022)

Waterpipe smoke condensate influences epithelial to mesenchymal transition and interferes with the cytotoxic immune response in non-small cell lung cancer cell lines
por: Zaarour, Rania Faouzi, et al.
Publicado: (2021)

Chronic hypoxia is associated with transcriptomic reprogramming and increased genomic instability in cancer cells
por: Abou Khouzam, Raefa, et al.
Publicado: (2023)

Tumor hypoxia: an important regulator of tumor progression or a potential modulator of tumor immunogenicity?
por: Hassan Venkatesh, Goutham, et al.
Publicado: (2021)

Tumor Hypoxia Regulates Immune Escape/Invasion: Influence on Angiogenesis and Potential Impact of Hypoxic Biomarkers on Cancer Therapies
por: Abou Khouzam, Raefa, et al.
Publicado: (2021)

The expanding impact of T-regs in the skin
por: Hajam, Edries Yousaf, et al.
Publicado: (2022)

Hypoxia increases mutational load of breast cancer cells through frameshift mutations
por: Hassan Venkatesh, Goutham, et al.
Publicado: (2020)

An Eight-Gene Hypoxia Signature Predicts Survival in Pancreatic Cancer and Is Associated With an Immunosuppressed Tumor Microenvironment
por: Abou Khouzam, Raefa, et al.
Publicado: (2021)

Hypoxia increases melanoma-associated fibroblasts immunosuppressive potential and inhibitory effect on T cell-mediated cytotoxicity
por: Ziani, Linda, et al.
Publicado: (2021)

Dissecting the Role of AXL in Cancer Immune Escape and Resistance to Immune Checkpoint Inhibition
por: Engelsen, Agnete S. T., et al.
Publicado: (2022)

Role of Hypoxic Stress in Regulating Tumor Immunogenicity, Resistance and Plasticity
por: Terry, Stéphane, et al.
Publicado: (2018)

Decoding cancer’s camouflage: epithelial-mesenchymal plasticity in resistance to immune checkpoint blockade
por: Lotsberg, Maria L., et al.
Publicado: (2020)

Alteration of the Antitumor Immune Response by Cancer-Associated Fibroblasts
por: Ziani, Linda, et al.
Publicado: (2018)

The pharmalogical reactivation of p53 function improves breast tumor cell lysis by granzyme B and NK cells through induction of autophagy
por: Chollat-Namy, Marie, et al.
Publicado: (2019)

The Promise of Targeting Hypoxia to Improve Cancer Immunotherapy: Mirage or Reality?
por: Janji, Bassam, et al.
Publicado: (2022)

The matrix protein Fibulin-5 is at the interface of tissue stiffness and inflammation in fibrosis
por: Nakasaki, Manando, et al.
Publicado: (2015)

“Suffocating” tumors by blocking adaptation to hypoxia: a new headway in melanoma immunotherapy
por: Janji, Bassam, et al.
Publicado: (2021)

The role of hypoxia in shaping the recruitment of proangiogenic and immunosuppressive cells in the tumor microenvironment
por: Chouaib, Salem, et al.
Publicado: (2018)

Tumor microenvironment-induced tumor cell plasticity: relationship with hypoxic stress and impact on tumor resistance
por: Zaarour, RF., et al.
Publicado: (2023)

Targeting Autophagy in the Tumor Microenvironment: New Challenges and Opportunities for Regulating Tumor Immunity
por: Janji, Bassam, et al.
Publicado: (2018)

The multifaceted role of autophagy in tumor evasion from immune surveillance
por: Janji, Bassam, et al.
Publicado: (2016)

Critical Role of Tumor Microenvironment in Shaping NK Cell Functions: Implication of Hypoxic Stress
por: Hasmim, Meriem, et al.
Publicado: (2015)

AXL Targeting Abrogates Autophagic Flux and Induces Immunogenic Cell Death in Drug-Resistant Cancer Cells
por: Lotsberg, Maria L., et al.
Publicado: (2020)

Hypoxia Promotes Tumor Growth in Linking Angiogenesis to Immune Escape
por: Chouaib, Salem, et al.
Publicado: (2012)

Novel Points of Attack for Targeted Cancer Therapy
por: Røsland, Gro Vatne, et al.
Publicado: (2015)

Hijacker of the Antitumor Immune Response: Autophagy Is Showing Its Worst Facet
por: Viry, Elodie, et al.
Publicado: (2016)

Melanoma-associated fibroblasts decrease tumor cell susceptibility to NK cell-mediated killing through matrix-metalloproteinases secretion
por: Ziani, Linda, et al.
Publicado: (2017)

Selection of tumor-resistant variants following sustained natural killer cell-mediated immune stress
por: Carré, Thibault, et al.
Publicado: (2021)

Dysferlin Interacts with Tubulin and Microtubules in Mouse Skeletal Muscle
por: Azakir, Bilal A., et al.
Publicado: (2010)

Dysferlin Interacts with Histone Deacetylase 6 and Increases alpha-Tubulin Acetylation
por: Di Fulvio, Sabrina, et al.
Publicado: (2011)

Hypoxia, a Targetable Culprit to Counter Pancreatic Cancer Resistance to Therapy
por: Abou Khouzam, Raefa, et al.
Publicado: (2023)

The Most Common VHL Point Mutation R167Q in Hereditary VHL Disease Interferes with Cell Plasticity Regulation
por: Buart, Stéphanie, et al.
Publicado: (2021)

New insights into the role of EMT in tumor immune escape
por: Terry, Stéphane, et al.
Publicado: (2017)

Hypoxia differently modulates the release of mitochondrial and nuclear DNA
por: Otandault, Amaelle, et al.
Publicado: (2020)

Knowledge and attitudes of physicians toward research ethics and scientific misconduct in Lebanon
por: Azakir, Bilal, et al.
Publicado: (2020)

Regulated secretion
por: Jamora, Colin
Publicado: (2000)

Death by autophagy
por: Wells, William A.
Publicado: (2002)

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation
por: Noman, Muhammad Zaeem, et al.
Publicado: (2014)

Controlling the Secondary Surface Morphology of Electrospun PVDF Nanofibers by Regulating the Solvent and Relative Humidity
por: Zaarour, Bilal, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_lfjuq48dvpdvoqb83ac5hb07s8