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6mA-Pred: identifying DNA N6-methyladenine sites based on deep learning
With the accumulation of data on 6mA modification sites, an increasing number of scholars have begun to focus on the identification of 6mA sites. Despite the recognized importance of 6mA sites, methods for their identification remain lacking, with most existing methods being aimed at their identific...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PeerJ Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866889/ https://www.ncbi.nlm.nih.gov/pubmed/33604189 http://dx.doi.org/10.7717/peerj.10813 |
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author | Huang, Qianfei Zhou, Wenyang Guo, Fei Xu, Lei Zhang, Lichao |
author_facet | Huang, Qianfei Zhou, Wenyang Guo, Fei Xu, Lei Zhang, Lichao |
author_sort | Huang, Qianfei |
collection | PubMed |
description | With the accumulation of data on 6mA modification sites, an increasing number of scholars have begun to focus on the identification of 6mA sites. Despite the recognized importance of 6mA sites, methods for their identification remain lacking, with most existing methods being aimed at their identification in individual species. In the present study, we aimed to develop an identification method suitable for multiple species. Based on previous research, we propose a method for 6mA site recognition. Our experiments prove that the proposed 6mA-Pred method is effective for identifying 6mA sites in genes from taxa such as rice, Mus musculus, and human. A series of experimental results show that 6mA-Pred is an excellent method. We provide the source code used in the study, which can be obtained from http://39.100.246.211:5004/6mA_Pred/. |
format | Online Article Text |
id | pubmed-7866889 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | PeerJ Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78668892021-02-17 6mA-Pred: identifying DNA N6-methyladenine sites based on deep learning Huang, Qianfei Zhou, Wenyang Guo, Fei Xu, Lei Zhang, Lichao PeerJ Bioinformatics With the accumulation of data on 6mA modification sites, an increasing number of scholars have begun to focus on the identification of 6mA sites. Despite the recognized importance of 6mA sites, methods for their identification remain lacking, with most existing methods being aimed at their identification in individual species. In the present study, we aimed to develop an identification method suitable for multiple species. Based on previous research, we propose a method for 6mA site recognition. Our experiments prove that the proposed 6mA-Pred method is effective for identifying 6mA sites in genes from taxa such as rice, Mus musculus, and human. A series of experimental results show that 6mA-Pred is an excellent method. We provide the source code used in the study, which can be obtained from http://39.100.246.211:5004/6mA_Pred/. PeerJ Inc. 2021-02-03 /pmc/articles/PMC7866889/ /pubmed/33604189 http://dx.doi.org/10.7717/peerj.10813 Text en © 2021 Huang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited. |
spellingShingle | Bioinformatics Huang, Qianfei Zhou, Wenyang Guo, Fei Xu, Lei Zhang, Lichao 6mA-Pred: identifying DNA N6-methyladenine sites based on deep learning |
title | 6mA-Pred: identifying DNA N6-methyladenine sites based on deep learning |
title_full | 6mA-Pred: identifying DNA N6-methyladenine sites based on deep learning |
title_fullStr | 6mA-Pred: identifying DNA N6-methyladenine sites based on deep learning |
title_full_unstemmed | 6mA-Pred: identifying DNA N6-methyladenine sites based on deep learning |
title_short | 6mA-Pred: identifying DNA N6-methyladenine sites based on deep learning |
title_sort | 6ma-pred: identifying dna n6-methyladenine sites based on deep learning |
topic | Bioinformatics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866889/ https://www.ncbi.nlm.nih.gov/pubmed/33604189 http://dx.doi.org/10.7717/peerj.10813 |
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