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Association of CYP3A5 Gene Polymorphisms and Amlodipine-Induced Peripheral Edema in Chinese Han Patients with Essential Hypertension

BACKGROUND: Amlodipine is one of the most used members of calcium channel blockers (CCB), available to treat hypertension. It is mainly metabolized by the Cytochrome P450 3A4/5 (CYP3A4/5) in the liver. Peripheral edema emerges as the major adverse drug reaction to amlodipine and is the primary reaso...

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Detalles Bibliográficos
Autores principales:	Liang, Hao, Zhang, Xinru, Ma, Zhuo, Sun, Yan, Shu, Chang, Zhu, Yihua, Zhang, Yanwei, Hu, Songnian, Fu, Xiujuan, Liu, Lihong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866951/ https://www.ncbi.nlm.nih.gov/pubmed/33564260 http://dx.doi.org/10.2147/PGPM.S291277

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