Cargando…

New Antiproliferative Triflavanone from Thymelaea hirsuta—Isolation, Structure Elucidation and Molecular Docking Studies

In this study isolates from Thymelaea hirsuta, a wild plant from the Sinai Peninsula of Egypt, were identified and their selective cytotoxicity levels were evaluated. Phytochemical examination of the ethyl acetate (EtOAc) fraction of the methanolic (MeOH) extract of the plant led to the isolation of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Elhady, Sameh S., Abdelhameed, Reda F. A., El-Ayouty, Mayada M., Ibrahim, Amany K., Habib, Eman S., Elgawish, Mohamed S., Hassanean, Hashim A., Safo, Martin K., Nafie, Mohamed S., Ahmed, Safwat A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7867015/ https://www.ncbi.nlm.nih.gov/pubmed/33572651 http://dx.doi.org/10.3390/molecules26030739

Ejemplares similares

Phytochemical Screening, Antifungal, and Anticancer Activities of Medicinal Plants Thymelaea Hirsuta, Urginea Maritima, and Plantago Albicans
por: El-Bondkly, Esraa Ahmed Mohamed, et al.
Publicado: (2022)

In vivo anti-inflammatory and antiarthritic activities of aqueous extracts from Thymelaea hirsuta
por: Azza, Zora, et al.
Publicado: (2015)

DNA Barcoding of Two Thymelaeaceae Species: Daphne mucronata Royle and Thymelaea hirsuta (L.) Endl
por: Alkaraki, Almuthanna K., et al.
Publicado: (2021)

Antiproliferative Scalarane-Based Metabolites from the Red Sea Sponge Hyrtios erectus
por: Elhady, Sameh S., et al.
Publicado: (2016)

Potent and Selective Activity against Human Immunodeficiency Virus 1 (HIV-1) of Thymelaea hirsuta Extracts
por: Sanna, Giuseppina, et al.
Publicado: (2020)

Beneficial Effect of Thymelaea hirsuta on Pancreatic Islet Degeneration, Renal Fibrosis, and Liver Damages as Demonstrated in Streptozotocin-Induced Diabetic Rat
por: Abid, Sanae, et al.
Publicado: (2021)

VEGFR-Mediated Cytotoxic Activity of Pulicaria undulata Isolated Metabolites: A Biological Evaluation and In Silico Study
por: Elhady, Sameh S., et al.
Publicado: (2021)

Synthesis, 3D-QSAR, and Molecular Modeling Studies of Triazole Bearing Compounds as a Promising Scaffold for Cyclooxygenase-2 Inhibition
por: Elrayess, Ranza, et al.
Publicado: (2020)

Chemical Composition of the Red Sea Green Algae Ulva lactuca: Isolation and In Silico Studies of New Anti-COVID-19 Ceramides
por: Eltamany, Enas E., et al.
Publicado: (2021)

Exploring the anti-obesity bioactive compounds of Thymelaea hirsuta and Ziziphus spina-christi through integration of lipase inhibition screening and molecular docking analysis
por: Abdallah, Rokia M., et al.
Publicado: (2023)

A New Bioactive Metabolite Isolated from the Red Sea Marine Sponge Hyrtios erectus
por: Elhady, Sameh S., et al.
Publicado: (2016)

Anticancer Effects of New Ceramides Isolated from the Red Sea Red Algae Hypnea musciformis in a Model of Ehrlich Ascites Carcinoma: LC-HRMS Analysis Profile and Molecular Modeling
por: Elhady, Sameh S., et al.
Publicado: (2022)

Antioxidant and Anti-Inflammatory Activity of Cynanchum acutum L. Isolated Flavonoids Using Experimentally Induced Type 2 Diabetes Mellitus: Biological and In Silico Investigation for NF-κB Pathway/miR-146a Expression Modulation
por: Abdelhameed, Reda F. A., et al.
Publicado: (2021)

Aspergillus flavus YRB2 from Thymelaea hirsuta (L.) Endl., a non-aflatoxigenic endophyte with ability to overexpress defense-related genes against Fusarium root rot of maize
por: Rashad, Younes M., et al.
Publicado: (2022)

Chemical Profiling, Antioxidant, Cytotoxic Activities and Molecular Docking Simulation of Carrichtera annua DC. (Cruciferae)
por: Eltamany, Enas E., et al.
Publicado: (2020)

Cytotoxic, Apoptosis-Inducing Activities, and Molecular Docking of a New Sterol from Bamboo Shoot Skin Phyllostachys heterocycla var. pubescens
por: Abdelhameed, Reda F. A., et al.
Publicado: (2020)

Chemical Constituent Profiling of Phyllostachys heterocycla var. Pubescens with Selective Cytotoxic Polar Fraction through EGFR Inhibition in HepG2 Cells
por: Abdelhameed, Reda F. A., et al.
Publicado: (2021)

Thonningia sanguinea Extract: Antioxidant and Cytotoxic Activities Supported by Chemical Composition and Molecular Docking Simulations
por: Abdelhameed, Reda F. A., et al.
Publicado: (2021)

A New Saponin (Zygo-albuside D) from Zygophyllum album Roots Triggers Apoptosis in Non-Small Cell Lung Carcinoma (A549 Cells) through CDK-2 Inhibition
por: Eltamany, Enas E., et al.
Publicado: (2023)

Evaluation of 2-Thioxoimadazolidin-4-one Derivatives as Potent Anti-Cancer Agents through Apoptosis Induction and Antioxidant Activation: In Vitro and In Vivo Approaches
por: Nafie, Mohamed S., et al.
Publicado: (2021)

Antioxidant and Anti-inflammatory Properties of Algerian Thymelaea microphylla Coss. and Dur. Extracts
por: Dehimi, Khadidja, et al.
Publicado: (2016)

Comparative Cytotoxic Evaluation of Zygophyllum album Root and Aerial Parts of Different Extracts and Their Biosynthesized Silver Nanoparticles on Lung A549 and Prostate PC-3 Cancer Cell Lines
por: Abdelhameed, Reda F. A., et al.
Publicado: (2022)

LAMA-1: A Cerebroside Isolated from the Deep-Sea-Derived Fungus Penicillium chrysogenum (†)
por: Alshehri, Samah O., et al.
Publicado: (2020)

The Antioxidant Carrichtera annua DC. Ethanolic Extract Counteracts Cisplatin Triggered Hepatic and Renal Toxicities
por: Eltamany, Enas E., et al.
Publicado: (2021)

Elucidation of ligninolysis mechanism of a newly isolated white-rot basidiomycete Trametes hirsuta X-13
por: Ma, Jiangshan, et al.
Publicado: (2021)

Jaceidin Flavonoid Isolated from Chiliadenus montanus Attenuates Tumor Progression in Mice via VEGF Inhibition: In Vivo and In Silico Studies
por: Elhady, Sameh S., et al.
Publicado: (2020)

In Vitro Anti-Inflammatory Activity of Cotula anthemoides Essential Oil and In Silico Molecular Docking of Its Bioactives
por: Refaey, Mohamed S., et al.
Publicado: (2022)

Discovery of Potent Dual EGFR/HER2 Inhibitors Based on Thiophene Scaffold Targeting H1299 Lung Cancer Cell Line
por: Elrayess, Ranza, et al.
Publicado: (2020)

GC-MS/MS Quantification of EGFR Inhibitors, β-Sitosterol, Betulinic Acid, (+) Eriodictyol, (+) Epipinoresinol, and Secoisolariciresinol, in Crude Extract and Ethyl Acetate Fraction of Thonningia sanguinea
por: Elhady, Sameh S., et al.
Publicado: (2022)

New Cytotoxic Cerebrosides from the Red Sea Cucumber Holothuria spinifera Supported by In-Silico Studies
por: Abdelhameed, Reda F. A., et al.
Publicado: (2020)

Anti-Cryptosporidium parvum activity of Artemisia judaica L. and its fractions: in vitro and in vivo assays
por: Ahmed, Shahira A., et al.
Publicado: (2023)

Holospiniferoside: A New Antitumor Cerebroside from The Red Sea Cucumber Holothuria spinifera: In Vitro and In Silico Studies
por: Eltamany, Enas E., et al.
Publicado: (2021)

New Cytotoxic Natural Products from the Red Sea Sponge Stylissa carteri
por: Abdelhameed, Reda F. A., et al.
Publicado: (2020)

Draft Genome Sequence of the Fungus Trametes hirsuta 072
por: Pavlov, Andrey R., et al.
Publicado: (2015)

Large-Scale Production of Bioactive Terrein by Aspergillus terreus Strain S020 Isolated from the Saudi Coast of the Red Sea
por: Asfour, Hani Z., et al.
Publicado: (2019)

Draft Genome Sequence of the Moderately Thermophilic Actinobacterial Steroid-Transforming Saccharopolyspora hirsuta subsp. hirsuta Strain VKM Ac-666(T)
por: Lobastova, Tatyana G., et al.
Publicado: (2020)

Molecular Docking and Dynamics Simulation Study of Hyrtios erectus Isolated Scalarane Sesterterpenes as Potential SARS-CoV-2 Dual Target Inhibitors
por: Elhady, Sameh S., et al.
Publicado: (2021)

Phragmanthera austroarabica A.G.Mill. and J.A.Nyberg Triggers Apoptosis in MDA-MB-231 Cells In Vitro and In Vivo Assays: Simultaneous Determination of Selected Constituents
por: Goda, Marwa S., et al.
Publicado: (2022)

Design and Synthesis of Coumarin Derivatives as Cytotoxic Agents through PI3K/AKT Signaling Pathway Inhibition in HL60 and HepG2 Cancer Cells
por: Kishk, Safaa M., et al.
Publicado: (2022)

Specific Rhizobacteria Responsible in the Rhizosheath System of Kengyilia hirsuta
por: Chen, Youjun, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_26eln0rb6ppj6k4ltduqioi98s