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Risk Factors for Short-Term Lung Cancer Survival

Background: Lung cancer is typically diagnosed in an advanced phase of its natural history. Explanatory models based on epidemiological and clinical variables provide an approximation of patient survival less than one year using information extracted from the case history only, whereas models involv...

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Autores principales: Caballero-Vázquez, Alberto, Romero-Béjar, José Luis, Albendín-García, Luis, Suleiman-Martos, Nora, Gómez-Urquiza, José Luis, Cañadas, Gustavo Raúl, Cañadas-De la Fuente, Guillermo Arturo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7867142/
https://www.ncbi.nlm.nih.gov/pubmed/33535673
http://dx.doi.org/10.3390/jcm10030519
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author Caballero-Vázquez, Alberto
Romero-Béjar, José Luis
Albendín-García, Luis
Suleiman-Martos, Nora
Gómez-Urquiza, José Luis
Cañadas, Gustavo Raúl
Cañadas-De la Fuente, Guillermo Arturo
author_facet Caballero-Vázquez, Alberto
Romero-Béjar, José Luis
Albendín-García, Luis
Suleiman-Martos, Nora
Gómez-Urquiza, José Luis
Cañadas, Gustavo Raúl
Cañadas-De la Fuente, Guillermo Arturo
author_sort Caballero-Vázquez, Alberto
collection PubMed
description Background: Lung cancer is typically diagnosed in an advanced phase of its natural history. Explanatory models based on epidemiological and clinical variables provide an approximation of patient survival less than one year using information extracted from the case history only, whereas models involving therapeutic variables must confirm that any treatment applied is worse than surgery in survival terms. Models for classifying less than one year survival for patients diagnosed with lung cancer which are able to identify risk factors and quantify their effect for prognosis are analyzed. Method: Two stepwise binary logistic regression models, based on a retrospective study of 521 cases of patients diagnosed with lung cancer in the Interventional Pneumology Unit at the Hospital “Virgen de las Nieves”, Granada, Spain. Results: The first model included variables age, history of pulmonary neoplasm, tumor location, dyspnea, dysphonia, and chest pain. The independent risk factors age greater than 70 years, a peripheral location, dyspnea and dysphonia were significant. For the second model, treatments were also significant. Conclusions: Age, history of pulmonary neoplasm, tumor location, dyspnea, dysphonia, and chest pain are predictors for survival in patients diagnosed with lung cancer at the time of diagnosis. The treatment applied is significant for classifying less than one year survival time which confirms that any treatment is markedly inferior to surgery in terms of survival. This allows to consider applications of more or less aggressive treatments, anticipation of palliative cares or comfort measures, inclusion in clinical trials, etc.
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spelling pubmed-78671422021-02-07 Risk Factors for Short-Term Lung Cancer Survival Caballero-Vázquez, Alberto Romero-Béjar, José Luis Albendín-García, Luis Suleiman-Martos, Nora Gómez-Urquiza, José Luis Cañadas, Gustavo Raúl Cañadas-De la Fuente, Guillermo Arturo J Clin Med Article Background: Lung cancer is typically diagnosed in an advanced phase of its natural history. Explanatory models based on epidemiological and clinical variables provide an approximation of patient survival less than one year using information extracted from the case history only, whereas models involving therapeutic variables must confirm that any treatment applied is worse than surgery in survival terms. Models for classifying less than one year survival for patients diagnosed with lung cancer which are able to identify risk factors and quantify their effect for prognosis are analyzed. Method: Two stepwise binary logistic regression models, based on a retrospective study of 521 cases of patients diagnosed with lung cancer in the Interventional Pneumology Unit at the Hospital “Virgen de las Nieves”, Granada, Spain. Results: The first model included variables age, history of pulmonary neoplasm, tumor location, dyspnea, dysphonia, and chest pain. The independent risk factors age greater than 70 years, a peripheral location, dyspnea and dysphonia were significant. For the second model, treatments were also significant. Conclusions: Age, history of pulmonary neoplasm, tumor location, dyspnea, dysphonia, and chest pain are predictors for survival in patients diagnosed with lung cancer at the time of diagnosis. The treatment applied is significant for classifying less than one year survival time which confirms that any treatment is markedly inferior to surgery in terms of survival. This allows to consider applications of more or less aggressive treatments, anticipation of palliative cares or comfort measures, inclusion in clinical trials, etc. MDPI 2021-02-01 /pmc/articles/PMC7867142/ /pubmed/33535673 http://dx.doi.org/10.3390/jcm10030519 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Caballero-Vázquez, Alberto
Romero-Béjar, José Luis
Albendín-García, Luis
Suleiman-Martos, Nora
Gómez-Urquiza, José Luis
Cañadas, Gustavo Raúl
Cañadas-De la Fuente, Guillermo Arturo
Risk Factors for Short-Term Lung Cancer Survival
title Risk Factors for Short-Term Lung Cancer Survival
title_full Risk Factors for Short-Term Lung Cancer Survival
title_fullStr Risk Factors for Short-Term Lung Cancer Survival
title_full_unstemmed Risk Factors for Short-Term Lung Cancer Survival
title_short Risk Factors for Short-Term Lung Cancer Survival
title_sort risk factors for short-term lung cancer survival
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7867142/
https://www.ncbi.nlm.nih.gov/pubmed/33535673
http://dx.doi.org/10.3390/jcm10030519
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