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Factor XIII-A in Diseases: Role Beyond Blood Coagulation
Multidisciplinary research from the last few decades has revealed that Factor XIII subunit A (FXIII-A) is not only involved in blood coagulation, but may have roles in various diseases. Here, we aim to summarize data from studies involving patients with mutations in the F13A1 gene, performed in FXII...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7867190/ https://www.ncbi.nlm.nih.gov/pubmed/33535700 http://dx.doi.org/10.3390/ijms22031459 |
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author | Dull, Katalin Fazekas, Fruzsina Törőcsik, Dániel |
author_facet | Dull, Katalin Fazekas, Fruzsina Törőcsik, Dániel |
author_sort | Dull, Katalin |
collection | PubMed |
description | Multidisciplinary research from the last few decades has revealed that Factor XIII subunit A (FXIII-A) is not only involved in blood coagulation, but may have roles in various diseases. Here, we aim to summarize data from studies involving patients with mutations in the F13A1 gene, performed in FXIII-A knock-out mice models, clinical and histological studies assessing correlations between diseases severity and FXIII-A levels, as well as from in vitro experiments. By providing a complex overview on its possible role in wound healing, chronic inflammatory bowel diseases, athe-rosclerosis, rheumatoid arthritis, chronic inflammatory lung diseases, chronic rhinosinusitis, solid tumors, hematological malignancies, and obesity, we also demonstrate how the field evolved from using FXIII-A as a marker to accept and understand its active role in inflammatory and malignant diseases. |
format | Online Article Text |
id | pubmed-7867190 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-78671902021-02-07 Factor XIII-A in Diseases: Role Beyond Blood Coagulation Dull, Katalin Fazekas, Fruzsina Törőcsik, Dániel Int J Mol Sci Review Multidisciplinary research from the last few decades has revealed that Factor XIII subunit A (FXIII-A) is not only involved in blood coagulation, but may have roles in various diseases. Here, we aim to summarize data from studies involving patients with mutations in the F13A1 gene, performed in FXIII-A knock-out mice models, clinical and histological studies assessing correlations between diseases severity and FXIII-A levels, as well as from in vitro experiments. By providing a complex overview on its possible role in wound healing, chronic inflammatory bowel diseases, athe-rosclerosis, rheumatoid arthritis, chronic inflammatory lung diseases, chronic rhinosinusitis, solid tumors, hematological malignancies, and obesity, we also demonstrate how the field evolved from using FXIII-A as a marker to accept and understand its active role in inflammatory and malignant diseases. MDPI 2021-02-01 /pmc/articles/PMC7867190/ /pubmed/33535700 http://dx.doi.org/10.3390/ijms22031459 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Dull, Katalin Fazekas, Fruzsina Törőcsik, Dániel Factor XIII-A in Diseases: Role Beyond Blood Coagulation |
title | Factor XIII-A in Diseases: Role Beyond Blood Coagulation |
title_full | Factor XIII-A in Diseases: Role Beyond Blood Coagulation |
title_fullStr | Factor XIII-A in Diseases: Role Beyond Blood Coagulation |
title_full_unstemmed | Factor XIII-A in Diseases: Role Beyond Blood Coagulation |
title_short | Factor XIII-A in Diseases: Role Beyond Blood Coagulation |
title_sort | factor xiii-a in diseases: role beyond blood coagulation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7867190/ https://www.ncbi.nlm.nih.gov/pubmed/33535700 http://dx.doi.org/10.3390/ijms22031459 |
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