Cargando…

Tracking Down the Epigenetic Footprint of HCV-Induced Hepatocarcinogenesis

Hepatitis C virus (HCV) is a major cause of death and morbidity globally and is a leading cause of hepatocellular carcinoma (HCC). Incidence of HCV infections, as well as HCV-related liver diseases, are increasing. Although now, with new direct acting antivirals (DAAs) therapy available, HCV is a cu...

Descripción completa

Detalles Bibliográficos
Autores principales: Domovitz, Tom, Gal-Tanamy, Meital
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7867330/
https://www.ncbi.nlm.nih.gov/pubmed/33540858
http://dx.doi.org/10.3390/jcm10030551
_version_ 1783648278121807872
author Domovitz, Tom
Gal-Tanamy, Meital
author_facet Domovitz, Tom
Gal-Tanamy, Meital
author_sort Domovitz, Tom
collection PubMed
description Hepatitis C virus (HCV) is a major cause of death and morbidity globally and is a leading cause of hepatocellular carcinoma (HCC). Incidence of HCV infections, as well as HCV-related liver diseases, are increasing. Although now, with new direct acting antivirals (DAAs) therapy available, HCV is a curable cancer-associated infectious agent, HCC prevalence is expected to continue to rise because HCC risk still persists after HCV cure. Understanding the factors that lead from HCV infection to HCC pre- and post-cure may open-up opportunities to novel strategies for HCC prevention. Herein, we provide an overview of the reported evidence for the induction of alterations in the transcriptome of host cells via epigenetic dysregulation by HCV infection and describe recent reports linking the residual risk for HCC post-cure with a persistent HCV-induced epigenetic signature. Specifically, we discuss the contribution of the epigenetic changes identified following HCV infection to HCC risk pre- and post-cure, the molecular pathways that are epigenetically altered, the downstream effects on expression of cancer-related genes, the identification of targets to prevent or revert this cancer-inducing epigenetic signature, and the potential contribution of these studies to early prognosis and prevention of HCC as an approach for reducing HCC-related mortality.
format Online
Article
Text
id pubmed-7867330
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-78673302021-02-07 Tracking Down the Epigenetic Footprint of HCV-Induced Hepatocarcinogenesis Domovitz, Tom Gal-Tanamy, Meital J Clin Med Review Hepatitis C virus (HCV) is a major cause of death and morbidity globally and is a leading cause of hepatocellular carcinoma (HCC). Incidence of HCV infections, as well as HCV-related liver diseases, are increasing. Although now, with new direct acting antivirals (DAAs) therapy available, HCV is a curable cancer-associated infectious agent, HCC prevalence is expected to continue to rise because HCC risk still persists after HCV cure. Understanding the factors that lead from HCV infection to HCC pre- and post-cure may open-up opportunities to novel strategies for HCC prevention. Herein, we provide an overview of the reported evidence for the induction of alterations in the transcriptome of host cells via epigenetic dysregulation by HCV infection and describe recent reports linking the residual risk for HCC post-cure with a persistent HCV-induced epigenetic signature. Specifically, we discuss the contribution of the epigenetic changes identified following HCV infection to HCC risk pre- and post-cure, the molecular pathways that are epigenetically altered, the downstream effects on expression of cancer-related genes, the identification of targets to prevent or revert this cancer-inducing epigenetic signature, and the potential contribution of these studies to early prognosis and prevention of HCC as an approach for reducing HCC-related mortality. MDPI 2021-02-02 /pmc/articles/PMC7867330/ /pubmed/33540858 http://dx.doi.org/10.3390/jcm10030551 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Domovitz, Tom
Gal-Tanamy, Meital
Tracking Down the Epigenetic Footprint of HCV-Induced Hepatocarcinogenesis
title Tracking Down the Epigenetic Footprint of HCV-Induced Hepatocarcinogenesis
title_full Tracking Down the Epigenetic Footprint of HCV-Induced Hepatocarcinogenesis
title_fullStr Tracking Down the Epigenetic Footprint of HCV-Induced Hepatocarcinogenesis
title_full_unstemmed Tracking Down the Epigenetic Footprint of HCV-Induced Hepatocarcinogenesis
title_short Tracking Down the Epigenetic Footprint of HCV-Induced Hepatocarcinogenesis
title_sort tracking down the epigenetic footprint of hcv-induced hepatocarcinogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7867330/
https://www.ncbi.nlm.nih.gov/pubmed/33540858
http://dx.doi.org/10.3390/jcm10030551
work_keys_str_mv AT domovitztom trackingdowntheepigeneticfootprintofhcvinducedhepatocarcinogenesis
AT galtanamymeital trackingdowntheepigeneticfootprintofhcvinducedhepatocarcinogenesis