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Tracking Down the Epigenetic Footprint of HCV-Induced Hepatocarcinogenesis
Hepatitis C virus (HCV) is a major cause of death and morbidity globally and is a leading cause of hepatocellular carcinoma (HCC). Incidence of HCV infections, as well as HCV-related liver diseases, are increasing. Although now, with new direct acting antivirals (DAAs) therapy available, HCV is a cu...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7867330/ https://www.ncbi.nlm.nih.gov/pubmed/33540858 http://dx.doi.org/10.3390/jcm10030551 |
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author | Domovitz, Tom Gal-Tanamy, Meital |
author_facet | Domovitz, Tom Gal-Tanamy, Meital |
author_sort | Domovitz, Tom |
collection | PubMed |
description | Hepatitis C virus (HCV) is a major cause of death and morbidity globally and is a leading cause of hepatocellular carcinoma (HCC). Incidence of HCV infections, as well as HCV-related liver diseases, are increasing. Although now, with new direct acting antivirals (DAAs) therapy available, HCV is a curable cancer-associated infectious agent, HCC prevalence is expected to continue to rise because HCC risk still persists after HCV cure. Understanding the factors that lead from HCV infection to HCC pre- and post-cure may open-up opportunities to novel strategies for HCC prevention. Herein, we provide an overview of the reported evidence for the induction of alterations in the transcriptome of host cells via epigenetic dysregulation by HCV infection and describe recent reports linking the residual risk for HCC post-cure with a persistent HCV-induced epigenetic signature. Specifically, we discuss the contribution of the epigenetic changes identified following HCV infection to HCC risk pre- and post-cure, the molecular pathways that are epigenetically altered, the downstream effects on expression of cancer-related genes, the identification of targets to prevent or revert this cancer-inducing epigenetic signature, and the potential contribution of these studies to early prognosis and prevention of HCC as an approach for reducing HCC-related mortality. |
format | Online Article Text |
id | pubmed-7867330 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-78673302021-02-07 Tracking Down the Epigenetic Footprint of HCV-Induced Hepatocarcinogenesis Domovitz, Tom Gal-Tanamy, Meital J Clin Med Review Hepatitis C virus (HCV) is a major cause of death and morbidity globally and is a leading cause of hepatocellular carcinoma (HCC). Incidence of HCV infections, as well as HCV-related liver diseases, are increasing. Although now, with new direct acting antivirals (DAAs) therapy available, HCV is a curable cancer-associated infectious agent, HCC prevalence is expected to continue to rise because HCC risk still persists after HCV cure. Understanding the factors that lead from HCV infection to HCC pre- and post-cure may open-up opportunities to novel strategies for HCC prevention. Herein, we provide an overview of the reported evidence for the induction of alterations in the transcriptome of host cells via epigenetic dysregulation by HCV infection and describe recent reports linking the residual risk for HCC post-cure with a persistent HCV-induced epigenetic signature. Specifically, we discuss the contribution of the epigenetic changes identified following HCV infection to HCC risk pre- and post-cure, the molecular pathways that are epigenetically altered, the downstream effects on expression of cancer-related genes, the identification of targets to prevent or revert this cancer-inducing epigenetic signature, and the potential contribution of these studies to early prognosis and prevention of HCC as an approach for reducing HCC-related mortality. MDPI 2021-02-02 /pmc/articles/PMC7867330/ /pubmed/33540858 http://dx.doi.org/10.3390/jcm10030551 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Domovitz, Tom Gal-Tanamy, Meital Tracking Down the Epigenetic Footprint of HCV-Induced Hepatocarcinogenesis |
title | Tracking Down the Epigenetic Footprint of HCV-Induced Hepatocarcinogenesis |
title_full | Tracking Down the Epigenetic Footprint of HCV-Induced Hepatocarcinogenesis |
title_fullStr | Tracking Down the Epigenetic Footprint of HCV-Induced Hepatocarcinogenesis |
title_full_unstemmed | Tracking Down the Epigenetic Footprint of HCV-Induced Hepatocarcinogenesis |
title_short | Tracking Down the Epigenetic Footprint of HCV-Induced Hepatocarcinogenesis |
title_sort | tracking down the epigenetic footprint of hcv-induced hepatocarcinogenesis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7867330/ https://www.ncbi.nlm.nih.gov/pubmed/33540858 http://dx.doi.org/10.3390/jcm10030551 |
work_keys_str_mv | AT domovitztom trackingdowntheepigeneticfootprintofhcvinducedhepatocarcinogenesis AT galtanamymeital trackingdowntheepigeneticfootprintofhcvinducedhepatocarcinogenesis |