Cargando…
From Liver Cirrhosis to Cancer: The Role of Micro-RNAs in Hepatocarcinogenesis
In almost all cases, hepatocellular carcinoma (HCC) develops as the endpoint of a sequence that starts with chronic liver injury, progresses to liver cirrhosis, and finally, over years and decades, results in liver cancer. Recently, the role of non-coding RNA such as microRNA (miRNA) has been demons...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7867354/ https://www.ncbi.nlm.nih.gov/pubmed/33540837 http://dx.doi.org/10.3390/ijms22031492 |
_version_ | 1783648283756855296 |
---|---|
author | Mohr, Raphael Özdirik, Burcin Lambrecht, Joeri Demir, Münevver Eschrich, Johannes Geisler, Lukas Hellberg, Teresa Loosen, Sven H. Luedde, Tom Tacke, Frank Hammerich, Linda Roderburg, Christoph |
author_facet | Mohr, Raphael Özdirik, Burcin Lambrecht, Joeri Demir, Münevver Eschrich, Johannes Geisler, Lukas Hellberg, Teresa Loosen, Sven H. Luedde, Tom Tacke, Frank Hammerich, Linda Roderburg, Christoph |
author_sort | Mohr, Raphael |
collection | PubMed |
description | In almost all cases, hepatocellular carcinoma (HCC) develops as the endpoint of a sequence that starts with chronic liver injury, progresses to liver cirrhosis, and finally, over years and decades, results in liver cancer. Recently, the role of non-coding RNA such as microRNA (miRNA) has been demonstrated in the context of chronic liver diseases and HCC. Moreover, data from a phase II trial suggested a potential role of microRNAs as therapeutics in hepatitis-C-virus infection, representing a significant risk factor for development of liver cirrhosis and HCC. Despite progress in the clinical management of chronic liver diseases, pharmacological treatment options for patients with liver cirrhosis and/or advanced HCC are still limited. With their potential to regulate whole networks of genes, miRNA might be used as novel therapeutics in these patients but could also serve as biomarkers for improved patient stratification. In this review, we discuss available data on the role of miRNA in the transition from liver cirrhosis to HCC. We highlight opportunities for clinical translation and discuss open issues applicable to future developments. |
format | Online Article Text |
id | pubmed-7867354 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-78673542021-02-07 From Liver Cirrhosis to Cancer: The Role of Micro-RNAs in Hepatocarcinogenesis Mohr, Raphael Özdirik, Burcin Lambrecht, Joeri Demir, Münevver Eschrich, Johannes Geisler, Lukas Hellberg, Teresa Loosen, Sven H. Luedde, Tom Tacke, Frank Hammerich, Linda Roderburg, Christoph Int J Mol Sci Review In almost all cases, hepatocellular carcinoma (HCC) develops as the endpoint of a sequence that starts with chronic liver injury, progresses to liver cirrhosis, and finally, over years and decades, results in liver cancer. Recently, the role of non-coding RNA such as microRNA (miRNA) has been demonstrated in the context of chronic liver diseases and HCC. Moreover, data from a phase II trial suggested a potential role of microRNAs as therapeutics in hepatitis-C-virus infection, representing a significant risk factor for development of liver cirrhosis and HCC. Despite progress in the clinical management of chronic liver diseases, pharmacological treatment options for patients with liver cirrhosis and/or advanced HCC are still limited. With their potential to regulate whole networks of genes, miRNA might be used as novel therapeutics in these patients but could also serve as biomarkers for improved patient stratification. In this review, we discuss available data on the role of miRNA in the transition from liver cirrhosis to HCC. We highlight opportunities for clinical translation and discuss open issues applicable to future developments. MDPI 2021-02-02 /pmc/articles/PMC7867354/ /pubmed/33540837 http://dx.doi.org/10.3390/ijms22031492 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mohr, Raphael Özdirik, Burcin Lambrecht, Joeri Demir, Münevver Eschrich, Johannes Geisler, Lukas Hellberg, Teresa Loosen, Sven H. Luedde, Tom Tacke, Frank Hammerich, Linda Roderburg, Christoph From Liver Cirrhosis to Cancer: The Role of Micro-RNAs in Hepatocarcinogenesis |
title | From Liver Cirrhosis to Cancer: The Role of Micro-RNAs in Hepatocarcinogenesis |
title_full | From Liver Cirrhosis to Cancer: The Role of Micro-RNAs in Hepatocarcinogenesis |
title_fullStr | From Liver Cirrhosis to Cancer: The Role of Micro-RNAs in Hepatocarcinogenesis |
title_full_unstemmed | From Liver Cirrhosis to Cancer: The Role of Micro-RNAs in Hepatocarcinogenesis |
title_short | From Liver Cirrhosis to Cancer: The Role of Micro-RNAs in Hepatocarcinogenesis |
title_sort | from liver cirrhosis to cancer: the role of micro-rnas in hepatocarcinogenesis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7867354/ https://www.ncbi.nlm.nih.gov/pubmed/33540837 http://dx.doi.org/10.3390/ijms22031492 |
work_keys_str_mv | AT mohrraphael fromlivercirrhosistocancertheroleofmicrornasinhepatocarcinogenesis AT ozdirikburcin fromlivercirrhosistocancertheroleofmicrornasinhepatocarcinogenesis AT lambrechtjoeri fromlivercirrhosistocancertheroleofmicrornasinhepatocarcinogenesis AT demirmunevver fromlivercirrhosistocancertheroleofmicrornasinhepatocarcinogenesis AT eschrichjohannes fromlivercirrhosistocancertheroleofmicrornasinhepatocarcinogenesis AT geislerlukas fromlivercirrhosistocancertheroleofmicrornasinhepatocarcinogenesis AT hellbergteresa fromlivercirrhosistocancertheroleofmicrornasinhepatocarcinogenesis AT loosensvenh fromlivercirrhosistocancertheroleofmicrornasinhepatocarcinogenesis AT lueddetom fromlivercirrhosistocancertheroleofmicrornasinhepatocarcinogenesis AT tackefrank fromlivercirrhosistocancertheroleofmicrornasinhepatocarcinogenesis AT hammerichlinda fromlivercirrhosistocancertheroleofmicrornasinhepatocarcinogenesis AT roderburgchristoph fromlivercirrhosistocancertheroleofmicrornasinhepatocarcinogenesis |