Cargando…

TNRC6C Functions as a Tumor Suppressor and Is Frequently Downregulated in Papillary Thyroid Cancer

Our previous study found that trinucleotide repeat containing adaptor 6C (TNRC6C) may act as a tumor suppressor in papillary thyroid cancer (PTC). In this study, we aimed to confirm the effect of TNRC6C on PTC and investigate the underlying molecular mechanism. The difference of mRNA level of TNRC6C...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cai, Zhenqin, Zhai, Tianyu, Muhanhali, Dilidaer, Ling, Yan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7867448/ https://www.ncbi.nlm.nih.gov/pubmed/33564303 http://dx.doi.org/10.1155/2021/6686998

Ejemplares similares

Long Non-coding Antisense RNA TNRC6C-AS1 Is Activated in Papillary Thyroid Cancer and Promotes Cancer Progression by Suppressing TNRC6C Expression
por: Muhanhali, Dilidaer, et al.
Publicado: (2018)

Molecular basis for GIGYF–TNRC6 complex assembly
por: Sobti, Meghna, et al.
Publicado: (2023)

TNRC6C-AS1 Promotes Thyroid Cancer Progression by Upregulating LPAR5 via miR-513c-5p
por: Tong, Chuanming, et al.
Publicado: (2021)

Impact of scaffolding protein TNRC6 paralogs on gene expression and splicing
por: Johnson, Samantha T., et al.
Publicado: (2021)

Consequences of depleting TNRC6, AGO, and DROSHA proteins on expression of microRNAs
por: Johnson, Krystal C., et al.
Publicado: (2023)

NOL4 is Downregulated and Hyper-Methylated in Papillary Thyroid Carcinoma Suggesting Its Role as a Tumor Suppressor Gene
por: Sheikholeslami, Sara, et al.
Publicado: (2020)

Trinucleotide repeat containing 6c (TNRC6c) is essential for microvascular maturation during distal airspace sacculation in the developing lung
por: Guo, Hua, et al.
Publicado: (2017)

Structural characterisation of TNRC6A nuclear localisation signal in complex with importin-alpha
por: Chaston, Jessica J., et al.
Publicado: (2017)

Impact of Hypothyroidism on Echocardiographic Characteristics of Patients With Heart Valve Disease: A Single-Center Propensity Score-Based Study
por: Zhai, Tianyu, et al.
Publicado: (2020)

Characterization of the novel tumor-suppressor gene CCDC67 in papillary thyroid carcinoma
por: Yin, De-Tao, et al.
Publicado: (2015)

Promoter Methylation of Four Tumor Suppressor Genes in Human Papillary Thyroid Carcinoma
por: Khatami, Fatemeh, et al.
Publicado: (2019)

Hypervascularity is more frequent in medullary thyroid carcinoma: Compared with papillary thyroid carcinoma
por: Lai, Xingjian, et al.
Publicado: (2016)

Identification of Phosphorylated Amino Acids in Human TNRC6A C-Terminal Region and Their Effects on the Interaction with the CCR4-NOT Complex
por: Munakata, Fusako, et al.
Publicado: (2021)

Suppression of long non‐coding RNA TNRC6C‐AS1 protects against thyroid carcinoma through DNA demethylation of STK4 via the Hippo signalling pathway
por: Yang, Liu‐Xue, et al.
Publicado: (2019)

Long non‐coding RNA TNRC6C‐AS1 promotes methylation of STK4 to inhibit thyroid carcinoma cell apoptosis and autophagy via Hippo signalling pathway
por: Peng, Xinzhi, et al.
Publicado: (2019)

Control of the localization and function of a miRNA silencing component TNRC6A by Argonaute protein
por: Nishi, Kenji, et al.
Publicado: (2015)

Expression of TNRC6 (GW182) Proteins Is Not Necessary for Gene Silencing by Fully Complementary RNA Duplexes
por: Liu, Zhongtian, et al.
Publicado: (2019)

MiR-145 functions as a tumor suppressor in Papillary Thyroid Cancer by inhibiting RAB5C
por: Zhang, Wei, et al.
Publicado: (2020)

BRAF-activated LncRNA functions as a tumor suppressor in papillary thyroid cancer
por: Liao, Tian, et al.
Publicado: (2016)

VHL tumor suppressor as a novel potential candidate biomarker in papillary thyroid carcinoma
por: Todorović, Lidija, et al.
Publicado: (2023)

OR09-2 The RCAN 1.4 Metastasis Progression Suppressor Gene is Hypermethylated at Intron 1 and Downregulated in Papillary Thyroid Cancer
por: Li, Wei, et al.
Publicado: (2022)

Downregulation of Long Noncoding RNA LINC00261 Attenuates Myocardial Infarction through the miR-522-3p/Trinucleotide Repeat-Containing Gene 6a (TNRC6A) Axis
por: Jiang, Chaoxin, et al.
Publicado: (2021)

A novel tumor suppressor gene NCOA5 is correlated with progression in papillary thyroid carcinoma
por: Zheng, Zhou-Ci, et al.
Publicado: (2018)

TET1 is a Tumor Suppressor That Inhibits Papillary Thyroid Carcinoma Cell Migration and Invasion
por: Yu, Shuang, et al.
Publicado: (2020)

TNRC6 proteins modulate hepatitis C virus replication by spatially regulating the binding of miR-122/Ago2 complexes to viral RNA
por: Li, You, et al.
Publicado: (2019)

Long Non-Coding RNA NLIPMT as a Tumor Suppressor and Inhibitor of Cell Proliferation and Metastasis in Papillary Thyroid Carcinoma
por: Zhang, Fen, et al.
Publicado: (2020)

miR-199a-3p displays tumor suppressor functions in papillary thyroid carcinoma
por: Minna, Emanuela, et al.
Publicado: (2014)

XBP1s Acts as a Tumor Suppressor to Inhibit the EMT Process and Metastasis of Papillary Thyroid Cancer
por: Yang, Wen, et al.
Publicado: (2021)

miR-137 acts as a tumor suppressor in papillary thyroid carcinoma by targeting CXCL12
por: Dong, Su, et al.
Publicado: (2021)

Ago-TNRC6 complex triggers microRNA-mediated mRNA decay by promoting biphasic deadenylation followed by decapping
por: Chen, Chyi-Ying A., et al.
Publicado: (2009)

CMTM4 is frequently downregulated and functions as a tumour suppressor in clear cell renal cell carcinoma
por: Li, Ting, et al.
Publicado: (2015)

Frequent microdeletions in conventional papillary thyroid carcinoma detected by high-density oligonucleotide microarrays
por: Al-Ahmadi, Alaa, et al.
Publicado: (2014)

TNRC9 rs12443621 and FGFR2 rs2981582 polymorphisms and breast cancer risk
por: Chen, Ying, et al.
Publicado: (2016)

Weight Gain and Body Composition Changes during the Transition of Thyroid Function in Patients with Graves' Disease Undergoing Radioiodine Treatment
por: Cai, Zhenqin, et al.
Publicado: (2022)

Kruppel-like factor 13 acts as a tumor suppressor in thyroid carcinoma by downregulating IFIT1
por: Liu, Yang, et al.
Publicado: (2023)

Association of BET1L and TNRC6B with uterine leiomyoma risk and its relevant clinical features in Han Chinese population
por: Liu, Bailing, et al.
Publicado: (2018)

Frequent Alteration of the Tumor Suppressor Gene APC in Sporadic Canine Colorectal Tumors
por: Youmans, Lydia, et al.
Publicado: (2012)

Association of Cigarette Smoking with Aberrant Methylation of the Tumor Suppressor Gene RARβ2 in Papillary Thyroid Cancer
por: Kiseljak-Vassiliades, Katja, et al.
Publicado: (2011)

Protocadherin 17 is a tumor suppressor and is frequently methylated in nasopharyngeal carcinoma
por: He, Ya, et al.
Publicado: (2019)

Downregulation of SMOC2 expression in papillary thyroid carcinoma and its prognostic significance
por: Kim, Hye Sung, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_3u7gheohija0j9gopa47mbflu8