Tractor uses local ancestry to enable inclusion of admixed individuals into GWAS and boost power

Admixed populations are routinely excluded from genomic studies due to concerns over population structure. Here, we present a statistical framework and software package, Tractor, to facilitate inclusion of admixed individuals in association studies by leveraging local ancestry. We test Tractor with...

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Detalles Bibliográficos
Autores principales: Atkinson, Elizabeth G., Maihofer, Adam X., Kanai, Masahiro, Martin, Alicia R., Karczewski, Konrad J., Santoro, Marcos L., Ulirsch, Jacob C., Kamatani, Yoichiro, Okada, Yukinori, Finucane, Hilary K., Koenen, Karestan C., Nievergelt, Caroline M., Daly, Mark J., Neale, Benjamin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7867648/
https://www.ncbi.nlm.nih.gov/pubmed/33462486
http://dx.doi.org/10.1038/s41588-020-00766-y

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