Prognostic nomogram for surgery of lung cancer in HIV-infected patients

BACKGROUND: This study aimed to establish an effective prognostic nomogram for surgery of lung cancer in HIV-infected patients. METHODS: The nomogram is based on a retrospective study of 51 patients who underwent lung cancer surgery at the Shanghai Public Health Clinical Center from July 2012 to Nov...

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Autores principales: Wang, Lin, Wu, Liwei, Liu, Jianjian, Wan, Laiyi, Chen, Hui, Zhu, Yijun, Wang, Jun, Li, Hongwei, Shi, Lei, Li, Leilei, Song, Yanzheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7867813/
https://www.ncbi.nlm.nih.gov/pubmed/33569187
http://dx.doi.org/10.21037/jtd-20-2268
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author Wang, Lin
Wu, Liwei
Liu, Jianjian
Wan, Laiyi
Chen, Hui
Zhu, Yijun
Wang, Jun
Li, Hongwei
Shi, Lei
Li, Leilei
Song, Yanzheng
author_facet Wang, Lin
Wu, Liwei
Liu, Jianjian
Wan, Laiyi
Chen, Hui
Zhu, Yijun
Wang, Jun
Li, Hongwei
Shi, Lei
Li, Leilei
Song, Yanzheng
author_sort Wang, Lin
collection PubMed
description BACKGROUND: This study aimed to establish an effective prognostic nomogram for surgery of lung cancer in HIV-infected patients. METHODS: The nomogram is based on a retrospective study of 51 patients who underwent lung cancer surgery at the Shanghai Public Health Clinical Center from July 2012 to November 2019. The predictive accuracy and discriminative ability of the nomogram were determined by concordance index (C-index) and calibration curve analysis. Internal validity was assessed using bootstrapping validation. RESULTS: Predictors contained in the prognostic nomogram included age, CD4+ cell count, surgery method, and pathological stage. The model displayed good discrimination with a C-index of 0.755 (95% CI: 0.715–0.795) and good calibration. A high C-index value of 0.844 was reached after internal validation. CONCLUSIONS: The proposed nomogram may result in more-accurate prognostic predictions for surgery of lung cancer in HIV-infected patients.
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spelling pubmed-78678132021-02-09 Prognostic nomogram for surgery of lung cancer in HIV-infected patients Wang, Lin Wu, Liwei Liu, Jianjian Wan, Laiyi Chen, Hui Zhu, Yijun Wang, Jun Li, Hongwei Shi, Lei Li, Leilei Song, Yanzheng J Thorac Dis Original Article BACKGROUND: This study aimed to establish an effective prognostic nomogram for surgery of lung cancer in HIV-infected patients. METHODS: The nomogram is based on a retrospective study of 51 patients who underwent lung cancer surgery at the Shanghai Public Health Clinical Center from July 2012 to November 2019. The predictive accuracy and discriminative ability of the nomogram were determined by concordance index (C-index) and calibration curve analysis. Internal validity was assessed using bootstrapping validation. RESULTS: Predictors contained in the prognostic nomogram included age, CD4+ cell count, surgery method, and pathological stage. The model displayed good discrimination with a C-index of 0.755 (95% CI: 0.715–0.795) and good calibration. A high C-index value of 0.844 was reached after internal validation. CONCLUSIONS: The proposed nomogram may result in more-accurate prognostic predictions for surgery of lung cancer in HIV-infected patients. AME Publishing Company 2021-01 /pmc/articles/PMC7867813/ /pubmed/33569187 http://dx.doi.org/10.21037/jtd-20-2268 Text en 2021 Journal of Thoracic Disease. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Wang, Lin
Wu, Liwei
Liu, Jianjian
Wan, Laiyi
Chen, Hui
Zhu, Yijun
Wang, Jun
Li, Hongwei
Shi, Lei
Li, Leilei
Song, Yanzheng
Prognostic nomogram for surgery of lung cancer in HIV-infected patients
title Prognostic nomogram for surgery of lung cancer in HIV-infected patients
title_full Prognostic nomogram for surgery of lung cancer in HIV-infected patients
title_fullStr Prognostic nomogram for surgery of lung cancer in HIV-infected patients
title_full_unstemmed Prognostic nomogram for surgery of lung cancer in HIV-infected patients
title_short Prognostic nomogram for surgery of lung cancer in HIV-infected patients
title_sort prognostic nomogram for surgery of lung cancer in hiv-infected patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7867813/
https://www.ncbi.nlm.nih.gov/pubmed/33569187
http://dx.doi.org/10.21037/jtd-20-2268
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